摘要
目的:了解阿立哌唑替换氯氮平治疗精神分裂症的有效性和安全性。方法:将氯氮平治疗4周疗效好转及以下的精神分裂症患者,共60例,随机分为阿立哌唑组和氯氮平组,疗程8周。用阳性与阴性症状量表(PANSS),大体评定量表(GAS),临床疗效总评量表病情严重程度(CG I-SI)和副反应量表(TESS)评定疗效及不良反应。结果:两组间疗效差异无显著性,阿立哌唑组无严重不良反应。结论:阿立哌唑替换氯氮平治疗精神分裂症安全有效。
Objective：To explore the therapeutic and side effects of aripiprazole in the treatment of schizophrenic patients who has response to clozapine. Methods：Sixty schizophrenic patients were treated with aripiprazole in place of clozapine. The efficacy was measured with the positive and negative symptoms scale （PANSS）, global assessment scale（GAS） and clinical global impression scale （ CGI - SI）, while the adverse events were determined by the treatment emergent symptoms scale （TESS）. Results： There were no significantly differences in therapeutic and side effects between two groups （P 〉 0.05 ）. Conclusions： It is suggested that aripiprazole in place of clozapine is effective exactly in the treatment of schizophrenic patients.
出处
《中国民康医学》
2006年第17期753-754,共2页
Medical Journal of Chinese People’s Health
