摘要
为了探讨一氧化氮(NO)、内皮素(ET)、P物质(SP)及CGRP免疫活性物质时慢性牙周炎的效应及与牙周炎的关系,分别应用免疫组织化学和组织化学染色方法,观察了20例慢性牙周炎患者牙龈组织中上述免疫活性物质表达情况,经定量分析结果表明NO和ET含量高于对照组,尤以ET显著(P<0.01),由于ET水平增强导致血流减少、供血不足,影响牙周活力致使牙周受损,因此提示NO及ET与牙周炎密切相关并起着重要作用。
InordertostudytheefectsofNO,endothelin(ET),substancep(SP)andcaleitongene-relatedpaptide(CGRP)immunoreactivesubstancesinchronicperiodontitistissueandtherelationshipwithperiodontitis,immunohistochemicalandhistochemicalstainingmethodswereusedrespectivelytodetecttheexpressionoftheaboveimmunoreativesubstancesin20patientswithchronicperiodontitis.QuantitativeanalysisshowedthatNOandETinperiodontitistissueswereincreasedsignificantly(P<0.01),particularlythecontentofET,incomparisontonormaltissue.DuetotheincreaseofETcontent,theboldsupplywasdiminishedandinfluencedtheperiodontaltissuebycausingtissuedamage.ThisstudysuggeststhatNOandETimmunoreactivesubstancesarecloselyassociatedwithperiodontitisandmayplayanimportantroleinthedisease.TherewerenomarkedchangesonSPandCGRP.
出处
《中华病理学杂志》
CAS
CSCD
北大核心
1996年第6期340-342,共3页
Chinese Journal of Pathology