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正常人与慢性牙周炎患者牙龈组织中免疫活性物质的观察 被引量:5

Aninvestigationofimmunoreactivesubstancesinnormalgingivaltissueandperiodontitistissue
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摘要 为了探讨一氧化氮(NO)、内皮素(ET)、P物质(SP)及CGRP免疫活性物质时慢性牙周炎的效应及与牙周炎的关系,分别应用免疫组织化学和组织化学染色方法,观察了20例慢性牙周炎患者牙龈组织中上述免疫活性物质表达情况,经定量分析结果表明NO和ET含量高于对照组,尤以ET显著(P<0.01),由于ET水平增强导致血流减少、供血不足,影响牙周活力致使牙周受损,因此提示NO及ET与牙周炎密切相关并起着重要作用。 InordertostudytheefectsofNO,endothelin(ET),substancep(SP)andcaleitongene-relatedpaptide(CGRP)immunoreactivesubstancesinchronicperiodontitistissueandtherelationshipwithperiodontitis,immunohistochemicalandhistochemicalstainingmethodswereusedrespectivelytodetecttheexpressionoftheaboveimmunoreativesubstancesin20patientswithchronicperiodontitis.QuantitativeanalysisshowedthatNOandETinperiodontitistissueswereincreasedsignificantly(P<0.01),particularlythecontentofET,incomparisontonormaltissue.DuetotheincreaseofETcontent,theboldsupplywasdiminishedandinfluencedtheperiodontaltissuebycausingtissuedamage.ThisstudysuggeststhatNOandETimmunoreactivesubstancesarecloselyassociatedwithperiodontitisandmayplayanimportantroleinthedisease.TherewerenomarkedchangesonSPandCGRP.
出处 《中华病理学杂志》 CAS CSCD 北大核心 1996年第6期340-342,共3页 Chinese Journal of Pathology
关键词 牙周炎 免疫组织化学 牙龈组织 ToothdiseasesImmunohistochemistry
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参考文献2

  • 1严焱,国外医学口腔学分册,1996年,23卷,131页
  • 2刘宝华,国外医学生理,病理与临床分册,1996年,16卷,45页

同被引文献24

  • 1陈世璋,宋子元,王跃.牙周炎患者牙龈组织中ET和NO改变与局部骨吸收的研究[J].中国骨质疏松杂志,1999,5(3):40-43. 被引量:9
  • 2陈兆聪.医学分子生物学[M].武汉大学出版社,1987..
  • 3Byers MR. Dynamic plasticity of Dental Sensory nerve structure and cytochemistry[J]. Arch Oral Biol, 1994, 39 Suppl: 13-21.
  • 4Grutzner E, Garry M, Hargreaves K, et al. Effect of injury on pulpal levels of immunoreactive Substance P and immunoreactive calcitonin gene-related peptide[J]. Endod, 1992, 18(11): 553-557.
  • 5Bartold PM, Kylstra A, Lawson R. Substance P: an immunohistochemical and biochemical study in human gingival tissues. A role for neurogenic inflammation? [J]. Periodontol,1994, 65(12): 1113-1121.
  • 6Gyorfi A, Fazekas A, Irmes F, et al. Role of substance P (SP) in the development of symptoms of neurogenic inflammation in the oral mucosa of the rat[J]. Periodontol Research, 1993, 28(3): 191 - 196.
  • 7Linden GJ, Mckinnell J, Shaw C, et al. Substance P and neurokinin Ain gingival crevicular fluid in periodontal health and disease [J]. Clin Periodontol, 1997,24(11):799 - 803.
  • 8Goto T, Yamaza T, Kido MA, et al. Light and electron-microscopic study of the distribution of axons containing substance P and the localization of neurokinin-1 receptor in bone[J]. Cell Tissue Res, 1998, 293(1):87-93.
  • 9Manthy PW. Substance P and the inflammatory and immune response [J]. Ann New York Acad Sci, 1991, 632:263-271.
  • 10陈桂珍,孙伟莲.牙周炎患者唾液一氧化氮的含量及其与牙周病指标相关性的研究[J].华西口腔医学杂志,1999,17(2):140-142. 被引量:13

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