摘要
为探讨肺大细胞癌（ＰＬＣＣ）分化表型及其临床病理意义，采用与分化表型有关的抗体：高分子量角蛋白（ＣＫ－ＨＭＷ）、低分子量角蛋白（ＣＫ－ＬＭＷ）、分泌成分（ＳＣ）、嗜铬颗粒蛋白Ａ（ＣｇＡ）、突触素（Ｓｙｎ），对６０例ＰＬＣＣ进行免疫组织化学研究。结果显示，６０例ＰＬＣＣ分别具有单向、双向及三向的分化表型特征。不同分化表型的ＰＬＣＣ患者中位生存期不同，向神经内分泌分化者和向腺分化者的生存期差异有显著意义（Ｐ＜０．０５）。结果表明：（１）ＰＬＣＣ具有不同的分化表型；（２）向神经内分泌分化者预后较差；（３）对ＰＬＣＣ进行分化表型分类是有必要的。
Thisstudywasdesignedtofindthediferentiatedphenotypeanditsclinicopathologicalsignificanceinpulmonarylargecelcarcinoam(PLCC)byimmunohistochemicalmethodsusingapanelofantibodiesrelatedtothephenotypediferentiation:highmolecularweightcytokeratinlowmolecularweightcytoker-atin,secretorycomponent,chrornograninAandsynaptophysinin60casesofPLCC.TheresultsdemonstratedthatalcasesofPLCCpossessedmonophasic,biphassicandtriphasicphenotypediferentiationfeaturesrespectively,includingsquamous(4cases),adenomatous(20cases),neuroen-docrine(19cases),adenosquamous(11cases);andthethecoexistenceofadenomatous,sqamousandneuroendocrine(6cases).Themediansurvivaltimewasdiferentbetweenpatientswithvariousdifer-entiatedphenotypesofPLCC.Therewasastatisticalysignificantdiference(P<0.05)insurvivalbe-tweenneuroendocrineandadenomatousphenotypes.Theresultsofthisstudyimpliesthat:(1)PLCCex-presseddifferentphenotypesofdiferentiation,(2)phenotypesofneuroendocringdiferentiationhasapoorprognosis,(3)itisnecessarytoclassifyPLCCaccordingtothephenotypedifferentiation.
出处
《中华病理学杂志》
CAS
CSCD
北大核心
1996年第6期347-350,共4页
Chinese Journal of Pathology
