摘要
目的:评价同步化疗加后程适形放射治疗III期非小细胞肺癌的疗效和并发症。方法:64例III期非小细胞肺癌患者随机分为二组(适形组与对照组),每组32例,先采用6/15MV-X线常规外放疗DT40Gy后,适形组采用三维适形放疗2.5Gy^3Gy/次,1次/d,累计量68Gy^72Gy;对照组采用常规外放疗2Gy/次,累计量64Gy^66Gy。化疗采用EP方案(足叶乙甙和顺铂)。结果:适形组与对照组1、2年生存率分别为87.5%、56.3%和65.6%、34.4%(P<0.05);局部制率分别为90.6%、81.3%和65.6%、53.1%(P<0.05)。结论:同步化疗加后程适形放射治疗可提高III期非小细胞肺癌的生存率,并未增加毒副反应。
Objective：To evaluate the efficacy and complications of chemotherapy and late course three - dimensional conformal, radiotherapy （3DCRT） for stage Ⅲ non -small cell lung cancer（NSCLC）. Methods： The 64 patients with stage Ⅲ NSCLC were randomized into two groups ： thirty - two patients received chemotherapy and late course 3DCRT （3DCRT group）, 32 patients received chemotherapy and conventional fraction radiation （control group） ,all patients were given with 6/15 MV X - ray total tumor dose was 40Gy , followed by 3DCRT,2.5Gy -3.0Gy per fraction , lfraction qd, total dose of 68Gy -70Gy, and followed by conventional fraction radiation, total dose of 64 -66Gy. Chemotherapy regimen was EP（ VP - 16 and DDP）. Results： The 1 and 2 -year survival rates in 3DCRT group and control group were 87. 5% ,56. 3% and 65.6% ,34.4% （ P 〈 0. 05 ） ; local control rates were 90.6% ,81.3% and 65.6% ,53.1% （P 〈0.05）. Conclusion： Chemotherapy and late course 3DCRT can improve the survival rate in stage Ⅲ NSCLC without severe toxicities.
出处
《现代肿瘤医学》
CAS
2006年第9期1090-1091,共2页
Journal of Modern Oncology
关键词
非小细胞肺癌
化疗
放射疗法
三维适形放疗
non- small cell lung cancer
chemotherapy
radiotherapy
three dimensional conformal radiotherapy
