摘要
目的:探讨银杏总内酯抗血栓形成及抑制血小板聚集的作用。方法:采用大鼠动静脉旁路血栓模型和Chandler氏血栓形成法,利用血小板活化因子(platelet activating factor,PAF)、花生四烯酸(arachi-donic acid,AA)和二磷酸腺苷(adenosine diphosphate,ADP)诱导家兔血小板聚集,测定血栓形成抑制率、血小板在不同时间点的聚集率以及最大聚集率。结果:银杏总内酯可不同程度地抑制大鼠动静脉旁路血栓和Chandler氏体外血栓形成,减轻血栓重量,血栓形成抑制率分别达到41.58%和59.31%;银杏总内酯可抑制PAF和ADP诱导的家兔血小板在不同时间点的聚集,降低其最大聚集率。结论:银杏总内酯可明显对抗血栓形成,并具有显著的抗PAF和ADP诱导血小板聚集作用。
AIM： To study the effect of total ginkgolides on platelet aggregation and experimental thrombosis. METHODS： The model of artery-vein bypass thrombosis and Chandler＇ s method were established to observe the effect of total ginkgolides. Platelet activating factor, arachidonic acid and adenosine diphosphate were used to induce platelet aggregation in rabbits and the ratio of platelet aggregation was detected. RESULTS： It was found that total ginkgolides inhibited the artery-vein bypass and Chandler＇s s thrombus in different degrees, reduced the thrombus weight significantly （either wet or dry,P 〈 0.01）; Total ginkgolides inhibited platelet aggregation with different revulsant at different time, and reduced the maximum aggregation rate. CONCLUSION： Total ginkgolides exerted remarkable effect against thrombosis and possessed strong effect against platelet aggrega- tion induced by ADP and PAF.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2006年第7期822-825,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
银杏总内酯
血栓形成
血小板聚集
total ginkgolides
thrombosis
platelet aggregation
