摘要
目的比较文拉法新与劳拉西泮的抗焦虑疗效和不良反应。方法72例符合CCMD-3诊断标准的广泛性焦虑症患者随机分为两组,分别给予文拉法新与劳拉西泮治疗6周。采用汉米乐顿焦虑量表(HAMA)评定临床疗效,副作用量表(TESS)评定不良反应。结果治疗6周,文拉法新组与劳拉西泮组有效率差异无显著性(文拉法新组有效率77.14%,劳拉西泮组为78.37%,P>0.05),文拉法新组不良反应以恶心、口干、头痛等较多,劳拉西泮组不良反应以头昏、嗜睡、乏力、震颤等多见,文拉法新组出现的不良反应比劳拉西泮组少且轻。结论文拉法新和劳拉西泮治疗广泛性焦虑疗效相当,不良反应较小。
Objective： To compared the anti - anxiety effect and side effect of Venlafaxine and Lorazepam. Methods： 72cases who met the CCMD - 3 criteria for generalized anxiety disorder （GAD） were divided into two groups randomly, treated with Venlafaxine and Lorazepam respectively for 6 weeks. Both groups were tested with Hamilton anxiety scale （HAMA） and Treatment Emergent Symptom Scale （TESS） to assess the thepapeutic efficacy and side effect respectively. Results：Venlafaxine was as effective as lorazepam for the treatment of generalized anxiety disorder （ P 〉 0.05 ）, there was no obvious difference between two groups in significant improvement rate （ P 〉 0. 05 ）. But Venlafaxine produced fewer of menstruation than lorazepam. The major side effect caused by Venlafaxine was vomit, thirsty, headache and the Lorazepam＇s side effect was dizzy, sleepy, weak and quake. Conclusion. Venlafaxine is as effective as lorazepam for the theatment of generalized anxiety disorder, and has fewer side effect.
出处
《上海精神医学》
2006年第4期228-229,221,共3页
Shanghai Archives of Psychiatry
关键词
文拉法新
劳拉西泮
广泛性焦虑症
Venlafaxine ,Lorazepam ,Generalized anxiety disorder
