摘要
目的探讨缬沙坦联用阿魏酸钠防治早期糖尿病肾病的作用。方法91例患者随机分成3组,常规组行常规治疗(n=28),缬沙坦组为常规治疗加缬沙坦治疗(n=31),联合组为常规治疗加缬沙坦与阿魏酸钠治疗(n=32);疗程1个月,并监测尿β2微球蛋白、尿微量白蛋白。结果缬沙坦组及联合组尿β2微球蛋白、尿微量白蛋白在治疗后明显下降;与常规组比较有显著差异性(P<0.01);联合组与缬沙坦组相比较,也有显著性差异(P<0.05)。结论缬沙坦联用阿魏酸钠可明显降低糖尿病早期肾病的尿白蛋白,防止其进展。
Objective To investigate the effect of valsartan combined sodium ferulate on the patients with early diabetic nepbropatby, Methods 91 cases with diabetic nepbropatby were randomly divided into three groups, including routine therapy （ 11 = 28）, Valsartan （ n = 31 ） and combination group （ 11 = 32）. The patients in above-mentioned three group bad been treated with routine drugs, valsartan ＋ routing drugs and valsartan ＋ sodium ferulate ＋ routine drugs respectively for one month, and their urinary album and β2- microglobulin （β2-MG） was measured. Results The levels of urinary album and β2-MG in combination treatment group were significantly lower compared with that in routine therapy group （ P 〈 0, 01 ）, and combination treatment has better effect than valsartan only （P 〈 0.05）. Conclusions Combination of Valsartan with ＇sodium ferulate can significantly decrease the albuminuria in the early diabetic nepbropatby and delay progress of the disease.
出处
《实用全科医学》
2006年第6期650-651,共2页
Applied Journal Of General Practice
关键词
缬沙坦
阿魏酸钠
糖尿病肾病
Valsartan
Sodium ferulate
Diabetic nephropathy
