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骨形态发生蛋白-7在肾脏病中的研究进展 被引量:4

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摘要 骨形态发生蛋白-7(BMP-7/OP-1)与肾脏疾病的发生、发展、转归密切相关。它不仅能够维持和促进正常肾组织的发育、形成,而且与肾脏纤维化、急性肾衰竭、糖尿病肾病、狼疮肾炎等关系密切。BMP-7在肾脏高度表达,能够减少血管钙化,改善钙磷代谢,同时具有抗肾脏纤维化作用。
作者 邓尧 樊均明
出处 《四川医学》 CAS 2006年第9期906-907,共2页 Sichuan Medical Journal
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  • 1Von BubnoffA,Cho KW.Intracellular BMP signaling regulation in vertebrates:pathway or network?[J].DevBiol,2001,239(1):1~14.
  • 2Miyazono K,Kusanagi K,Inoue H.Divergence and convergence of TGF-beta/BMP signaling[J].J Cell Physiol,2001,187(3):265~276.
  • 3Simon M,Maresh JG,Harris SE,et al.Expression of bone morphogenetic protein-7 mRNA in normal and ischemic adult rat kidney[J].Am J Physiol,1999,276(3):F382~F389.
  • 4Borovecki F,Jelic M,Grgurevic L,et al.Bone morphogenetic protein-7 from serum of pregnant mice is available to the fetus through placental transfer during early stages of development[J].Nephron Exp Nephrol,2004,97 (1):26~32.
  • 5Negri AL.Prevention of progressive fibrosis in chronic renal diseases:antifibrotic agents[J].J Nephrol,2004,17 (4):496~503.
  • 6Dube PH,Almanzar MM,Frazier KS.Osteogenic protein-1:gene expression and treatment in rat remnant kidney model[J].Toxicol Pathol,2004,32(4):384~392.
  • 7Ikeda Y,Jung YO,Kim H.Exogenous bone morphogenetic protein-7 fails to attenuate renal fibrosis in rats with overload proteinuria[J].Nephron Exp Nephrol,2004,97(4):123~135.
  • 8Zhang XL,Selbi W,Dela Motte C,et al.Bone morphogenic protein-7 inhibits monocyte-stimulated TGF-betal generation in renal proximal tubular epithelial cells[J].J Am Soc Nephrol,2005,16(1):79~89.
  • 9Zeisberg M,Hanai J,Sugimoto H,et al.BMP-7 countraccts TG F-β induces epithelial-to-mesenchymal transition and revers chronic renal injury[J].Nal Med,2003,9(7):964~968.
  • 10Wang SN,Lapage J,Himachberg R.Loss of tubular bone morphogenetic protein-7 in diabetic nephropathy[J].J Am Soc Nephrol,2001,12(11):2392~2399.

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