摘要
目的 通过分析凝固酶阴性葡萄球菌(CNS)的临床分布及耐药情况.为临床合理用药、提高感染的治愈率提供诊疗依据。方法 对2001年1月~2005年1月间666例CNS进行回顾性分析,数据经WHONET5软件分析检验。结果 共鉴定出12种CNS.广泛分布于17类临床标本中,呼吸道、泌尿道标本中CNS分离率最高.为34.4%及23.3%,以表皮葡萄球菌、溶血葡萄球菌和木糖葡萄球菌为主要菌种,药敏结果表明,各型CNS对万古霉素仍保持较高敏感率.妥布霉素、呋喃妥因、头孢他定相对敏感.耐药率〈30%.对青霉素、阿奇霉素、阿米卡星和氟哌酸耐药率均〉72%。结论 CNS广泛存在于各类临床标本中,可引起人体各器官的不同感染;万古霉素、妥布霉素、呋喃妥因、头孢他定应是治疗CNS的可选药物。
Objective To investigate the distribution and drug resistance of coagulase negative staphylococci (CNS) obtained from our hospital during the last 4 years. Methods 666 strains of CNS clinical isolates collected from Jan. 2001 to Jan. 2005 were analyzed. Results They were classified into 12 species of CNS with chemical technique. Staphylococcus epidermidis, staphylococcus haemolyticus and staphylococcus xylosus accounted for the majority. Drug susceptibility tests revealed that they were relatively sensitive to vancomycin, tobramycin, nitrofurantoin and ceftazidime( 〈 30 % ) but resistant to penicillin, azithromycin, amikacin and norfloxacin(〉70%). Ccoclusion Vancomycin, tobramycin, nitrofurantoin and ceftazidime are the best choices in the therapy of CNS infection.
出处
《重庆医学》
CAS
CSCD
2006年第17期1559-1560,共2页
Chongqing medicine
关键词
凝固酶阴性葡萄球菌
抗生素
耐药性
coagulase negative stapbyloeocci
antibiotics
drug resistance