摘要
系统性红斑狼疮(SLE)是多种因素相互作用引起的自身免疫性疾病,其发病机制复杂。近年来,随着对神经内分泌免疫网络的研究和认识日渐增多加深,发现催乳素(PRL)与多种自身免疫性疾病相关,如SLE、类风湿性关节炎、干燥综合征等,其中与SLE的关系最引人注目,但具体作用机制还未明确。PRL作为一个自分泌/旁分泌的细胞因子,在细胞因子网络中起着重要的作用,影响其他细胞因子的产生。分别从SLE与Th1/Th2型细胞因子分泌异常、PRL与Th1/Th2细胞因子分泌异常、SLE与PRL的关系等作简要的分析非常重要。
The pathogenesis of systemic lupus erythematosus （SLE） is extremely complicated, which involved muhifactorial interaction. As the knowledge about neuroendocrine-immune network has been further under stood： Evidences accumdated that prolactin （PRL） plays a role in the pathogenesis of many autoimmune diseases, such as SLE, rheumatoid arthritis, Sjogren＇s syndrome etc. Among them the relation-ship between PRL and SLE is remarkable. However, the exact mechanism on the pathogenesis of SLE remains elusive. PRL functions similarly to cytokine and plays an important role in the cytokine network. PRL acts in a paracrine and autocrine manner, which has an effect on the production of other cytokines. The relationships between SLE and Th1/Th2 cytokines parasecretion, PRL and Th1/Th2 cytokines parasecretion, and SLE and PRL had been reviewed in the paper.
出处
《国际免疫学杂志》
CAS
2006年第5期334-338,共5页
International Journal of Immunology
