摘要
用高效液相色谱（ＨＰＬＣ）测定大鼠给予没食子酸丙酯（ＰＧ）３０ｍｇ·ｋｇ－１后０．５，１．５，３．５，７．０，１０．０和３０．０ｍｉｎ的血浆浓度，分析所得血药－时浓度曲线符合二室开放性模型。大鼠ｉｐ双－对硝基苯磷酸酯钠（ＢＮＰＰ）３．４ｍｇ·ｋｇ－１，再ｉｖＰＧ３０ｍｇ·ｋｇ－１，所测ＰＧ血浆浓度与对照组有显著不同，其药物代谢动力学参数ｔ１／２α，ｔ１／２β，ｋ１０，ＡＵＣ以及ＭＲＴ（０－Ｉｎ）均较对照组延长或增加，两组间各参数比较均有显著或非常显著性差异；而ＣＬ也较对照组降低１倍；并且于ｉｖＰＧ５，１０及２０ｍｉｎ后其肝脏及血浆中ＰＧ含量也较对照组增高，两组之间比较均有显著性差异。结果表明ＢＮＰＰ对ＰＧ在大鼠体内的代谢速度有显著影响．
By using high performance liquid chromatography (HPLC), the plasma concentration of propyl gallate (PG) at 0.5, 1.5, 3.5, 7.0, 10.0 and 30.0 min after its administration in rats was measured. As a result, the pattern of blood concentration was conformed with the two-compartment open model. When rats were pretreated with bis-p-nitrophenyl- phophate sodium (BNPP) and followed by administration of PG, the plasma concentrations of PG were remarkably different from that of the control group. The values of t 1/2 α, t 1/2 β, k 10 , AUC and MRT(0-In) in groups pretreated with BNPP were considerably greater than those without BNPP (P<0.05, P<0.01, P<0.001), while CL of the former was the half of that of the latter. Furthermore, the concentrations of PG in liver and plasma at 5.0, 10.0 and 20.0 min after administration of PG were increased more sharply than those in the control group (P<0.05, P<0.01, P<0.001). These results suggest that BNPP influences the metabolism velocity of PG in rats.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1996年第4期290-293,共4页
Chinese Journal of Pharmacology and Toxicology
基金
国家自然科学基金
关键词
没食子酸丙酯
药动力学
赤芍801
propyl gallate
pharmacokinetics
carboxylesterases
high performance liquid chroma- tography
bis-p-nitrophenylphosphate sodium
