摘要
目的观察体外循环(CPB)中预充乌司他丁对CPB心脏病人血浆cTnl的影响。方法选择40例主动脉阻断时间在30 min以上的心脏直视手术患者随机分为两组,实验组和对照组各20例。实验组在常规CPB预充液中加入乌司他丁1.5万u/kg,对照组用生理盐水。分别在CPB前(T1),开放升主动脉时(T2),开放升主动脉30 min(T3),术毕12 h(T4),术毕24 h(T5),抽取桡动脉血,测定血浆cTnl的浓度。结果实验组患者cTnl在T3、T4、T5血浆浓度明显低于对照组(P<0.01)。结论乌司他丁可明显减少CPB术后cTnl的释放,对心肌缺血再灌注有保护作用。
Objective To investigate influence of ulinastin on the release of concentration of cTnI in plasma after Cardiopulmonary Bypass. Methods Forty patients scheduled for cardiac surgery under 30 rain following CPB were randomly divided into two groups. In treated group（ n = 20）, ulinastin was added into the prine before CPB. but in control group（ n = 20）, saline was added . Blood samples were drawn from the radial artery at the following intervals ： before CPB （ T1 ） , deelamping of aorta （ T2 ）, 30 min after deelamping of aorta （ T3 ）, 12 h after CPB （ T4 ）, 24 h after CPB （T5）. the concentration of cTnI in plasma level were measured. Results cTnI in the treated groups were significantly lower than those in the control group at T3, T4, T5 （ P 〈 0.01 ）. Conclusion Ulinastin can decrease the concentration of cTnI in plasma after CPB and may alleviate heart muscle ischemia reperfusion injury during cardiopulmonary bypass.
出处
《南华大学学报（医学版）》
2006年第2期213-214,241,共3页
Journal of Nanhua University(Medical Edition)
关键词
乌司他丁
心肺转流术
肌钙蛋白
心肌缺血
再灌注损伤
ulinastin
cardiopulmonary bypass
cardiae troponin
heart muscle ischemia
reperfusion injury
