摘要
Graves病和桥本甲状腺炎均属自身免疫性甲状腺疾病,其主要特征为甲状腺内不同程度的淋巴细胞和浆细胞的浸润、活化及针对自身抗原的免疫反应。CXC亚族趋化因子干扰素-γ诱导蛋白-10(IP-10)和干扰素-γ诱导单核细胞因子(Mig)在多种炎症细胞因子的调节下,通过与其受体CX-CR3结合使CXCR3阳性淋巴细胞向甲状腺炎症病灶迁移。活化的淋巴细胞通过介导抗原特异性的免疫应答和释放细胞因子导致腺体破坏继而损害甲状腺功能,在Graves病和桥本甲状腺炎的发生、发展中起重要作用。
Graves＇ disease and Hashimoto＇s thyroiditis belong to autoimmune thyroid disease. They are characterized by recruitment and activition of lymphocytes in thyroid and reactivation to self thyroid antigens. IFN-γ inducible protein-10 （IP-10） and monokine induced by IFN-γ （Mig） binding to the CXCR3 receptor are considered important in the migration of CXCR3 positive lymphocytes to the thyroid inflammatory foci under the regulation of several inflammatory cytokines. The activated lymphocytes can induce the destruction of the gland and later develop thyroid failure through reactivition of self thyroid antigens and production of cytokines. Therefore IP-10, Mig and CXCR3 play important roles in the pathogenesis of Graves＇ disease and Hashimoto＇s thyroiditis.
出处
《国际内分泌代谢杂志》
2006年第5期336-336,337-338,共3页
International Journal of Endocrinology and Metabolism
