摘要
目的观察益气活血中药对心气虚证家兔心功能的影响。方法用高脂饮食和免疫定向损伤法造模。分别以益气活血中药、天王补心丸、生理盐水灌胃。观察家兔一般情况、舌象。行左心室插管术,经Biolap-410生物信号分析系统比较心率(HR)、最大心室内压、平均心室内压、心室峰压平均值、心室内压力上升随时间的最大变化率(+dp/dt_(max))、最小心室内压、心室在等容舒张期内压力下降的最大变化率(-dp/dt_(min))、心电图ST-T的改变。结果造模组与各组间比较均有显著性差异(P＜0．05,P＜0．01)。大剂量组与阳性对照组比较(除HR、心室峰压平均值外)均有显著性差异(P＜0．05,P＜0．01)。造模组动物有不同程度ST-T改变,治疗组ECG的ST-T的改善优于阳性对照组(P＜0．05,P＜0．01)。结论心气虚证模型成立。益气活血中药是改善心脏舒缩功能的有效药物。
Objective To observe the influence of some Chinese herbal drugs with the effects of replenishing qi and activating blood on theheart function in rabbits with syndrome of heart-qi insufficiency. Method The model was established by feeding high fat diet and immune orientation lesion, and given orally Chinese herbal drugs, Tdianwangbuxin Pills and normal saline respectively. The general states and tongue manifestations of rabbits were observed. The heart rate （ HR）, maximum and average intraventricular pressure, mean value of ventricular peak pressure, ＋ dp/dtmax, minimum intraventricular pressure, - dp/dtmin in isovolumetric relaxation time （IVRT） and ST-T changes of ECG were compared by Biolap-410 bio-signal analystic system after the catheterization of left ventricle. Result The compatison was significant different between model group and other different groups （ P 〈 0. 05, P 〈 0.01 ）. The comparison was significantly different（ P 〈 0. 05, P 〈 0. 01 ） between the high-dose group and positive control group （ besides HR and mean value of ventricular peak pressure）. The model group had ST-T changes in varying degrees, and the relief of ST-T changes in the treatment groups was superior to that of the positive control group. Conclusion The model with the syndrome of heart-qi insufficiency is tenable. The Chinese herbal drugs with the effects of replenishing qi and activating blood are effectivefor improving the diastole and systole of the heart.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2006年第7期479-481,485,共4页
Journal of Beijing University of Traditional Chinese Medicine
基金
甘肃省教育厅科研项目(No.044B-09)
关键词
心气虚证
益气活血中药
天王补心丸
心功能
syndrome of heart-qi insufficiency
Chinese herbal drugs with the effects of replenishing qi and activating blood
Tdianwangbuxin Pills
heart function
