摘要
T细胞免疫球蛋白及粘蛋白域蛋白(Tim)基因家族有调节Th1和Th2细胞介导的免疫应答的作用。Tim1有共刺激T细胞增殖,促进细胞因子分泌的作用;Tim2主要表达于Th2细胞上;Tim3蛋白特异性表达于Th1细胞表面并且有抑制Th1细胞免疫功能的作用;Tim4是Tim1的天然配体。在哮喘和多发性硬化症的小鼠模型中,影响Tim分子的功能就会改变疾病的表型。因此,理解Tim分子如何调节Th1和Th2细胞效应功能的机制对免疫相关疾病的治疗和调变有重大意义。
The family of genes encoding T-cell immunoglobulin and mucin-domain containing proteins （Tim） are involved in the regulation of Thl- and Th2-cell-mediated immunity, timl costimulates T-cell expansion and cytokine production; tim2 is preferentially expressed on Th2 cells; tim3 protein is specifically expressed on Thl cells and negatively regulates Thl responses; tim4 is the ligand for tirol. In mouse models of asthma and multiple sclerosis, change of the function of Tim molecules leads to altered disease phenotype. Therefore, understanding how they regulate Thl- and Th2-effector functions will provide opportunities for the therapeutic modulation of immune-mediated diseases.
出处
《医学分子生物学杂志》
CAS
CSCD
2006年第5期357-360,共4页
Journal of Medical Molecular Biology
