摘要
目的评价托烷司琼预防腹腔镜胆囊切除术后病人恶心呕吐的效应。方法择期腹腔镜下行胆囊切除术病人60例,ASAⅠ或Ⅱ级,随机分为对照组和托烷司琼组,每组30例。采用常规的麻醉诱导和维持。术毕托烷司琼组静脉注射托烷司琼2 mg(用生理盐水稀释至5 ml),对照组给予等量生理盐水。观察术毕-术后24 h恶心、干呕和呕吐的发生率,并用评分法(0-10分)评估其程度,记录清醒程度评分及不良反应。结果与对照组相比,托烷司琼组术毕-术后3 h恶心、干呕和呕吐发生率及其程度降低,头痛和烦燥发生率降低;术后3-24 h干呕发生率及程度降低,恶心程度降低(P<0．05);清醒程度评分差异无统计学意义。结论托烷司琼可减少腹腔镜胆囊切除术病人恶心呕吐的发生及并降低其严重程度。
Objective To investigate the preventive effect of tropisetron against postoperative nausea and vomiting （PONV） after laparoscopic cholecystectomy. Methods Sixty ASA Ⅰ or Ⅱ patients aged 20-60 yrs weighing 48-70 kg were randomly divided into tropisetron group （ n = 30） and control group （ n = 30）. The patients were unpremedicated. Anesthesia was induced with midazolam, fentanyl, propofol and atracurium and maintained with isoflurane inhalation and intermittent Ⅳ boluses of fentanyl and atracurium. PETCO2 was maintained between 35-45 mm Hg. Tropisetron 2 mg（ in normal saline 5 ml） or normal saline 5 ml was given Ⅳ at the end of surgery. The incidence and intensity of PONV was graded from 0 （no PONV） to 10 （worst PONV）. Results Tropisetron significantly decreased the incidence and intensity of PONV after operation. The incidence of headache and restlessness were also significantly decreased after operation. Conclusion Tropisetron decreases the incidence and intensity of PONV after laparoscopic cholecystectomy.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2006年第7期609-611,共3页
Chinese Journal of Anesthesiology
关键词
止吐药
胆囊切除术
腹腔镜
手术后恶心呕吐
Antiemetics
Cholecystectomy, laparoscopic
Postoperative nausea and vomiting
