期刊文献+

肿瘤干细胞与骨肉瘤相关研究进展 被引量:1

下载PDF
导出
摘要 肿瘤研究中发现极少数有分化潜能,可无限增殖的亚细胞群具有干细胞特性,肿瘤的发生、生长、转移与之密切相关。肿瘤干细胞主要来源于成体干细胞,也可来源于祖细胞、分化细胞或骨髓细胞。白血病、乳腺癌、恶性脑瘤存在肿瘤干细胞已经明确,在前列腺癌、肺腺癌、肝癌、恶性黑色素瘤等多种肿瘤中也已初步分离出相应的肿瘤干细胞。骨肉瘤是常见的骨组织恶性肿瘤,肿瘤干细胞学说可更好地解释骨肉瘤恶性程度高、转移早、抗化疗等特性。应用无血清悬浮培养方法,干细胞样骨肉瘤细胞已初步得以分离、分析。该文就肿瘤于细胞及干细胞样骨肉瘤细胞的相关研究进展作一综述。
出处 《国际骨科学杂志》 2006年第5期269-272,共4页 International Journal of Orthopaedics
  • 相关文献

参考文献25

  • 1Marx J. Science. 2003; 301(5638):1308-1310.
  • 2Reya T, Morrison SJ, Clarke MF. et al. Nature, 2001; 414(6859):105-111.
  • 3Al-Hajj M. Wicha MS, Benito-Hemandez A, et al. Proc Natl Acad Sci USA.2003; 100(7):3983-3988.
  • 4Bonnet D, Dick JE. Nat Med, 1997; 3(7):730-737.
  • 5Pardal R, Clarke MF. Morrison SJ. Nat Rev Cancer. 2003; 3(12):895-902.
  • 6Bachoo RM, Maher EA. Ligon KL, et al, Cancer Cell. 2002; 1(3):269-277.
  • 7Rajaraman R, Rajaraman MM, Rajaraman SR, et al. Cell Biol Int. 2005; 99(12) :1084-1097.
  • 8Houghton J. Stoicov C, Nomura S, et al. Science, 2004; 306(5701):1568-1571.
  • 9Clarke MF, Morrison SJ, Wicha MS, et al. United States Patent Application: 20320119565, 2002.
  • 10Shackleton M, Vaillant F, Simpson KJ, et al. Nature, 2006; 439(7072):84-88.

二级参考文献19

  • 1李茗初,陈风华,邓永文,伍军,周仁辉,卢明,陈成,周向阳,方芳,方加胜.悬浮法培养C6胶质瘤细胞系和该细胞系中脑肿瘤干细胞的分离[J].中国现代医学杂志,2004,14(24):57-60. 被引量:20
  • 2Taylor M D, Mainprize T G.et al. Transcriptional profiling of medulloblastoma in chihtren [J]. J Neurosurg, 2003,99 (3) : 534-541.
  • 3Cairncross J G. The biology of astrocytonla: lessons learned from ehronic myelogenous leukemia-hypothesis [J].J Neurooncol, 1987,5(2) :99-104.
  • 4Reya T, Morrison S J, Clarke M F, et al. Stem cells, eancer, arid cancer stem cells [J]. Nature, 2001,414(6859): 105-111.
  • 5Singh S K, Clarke 1 D, Terasaki M, et al. identification of a eancer stem cell in human brain tumors [J]. Cancer Res, 2003,63(18) :5821-5828.
  • 6Hemmati H D, Nakano 1, Lazareff J A,et al. Cancerous stem cells can arise from pediatric brain tumors [J]. Proe Natl Acad Sci USA, 2003, 100(25):15178-15183.
  • 7Singh S K, Hawkins C, Clarke 1 D,et al. hlentificatinn of human brain tumnur initiating cells [J]. Nature,2004,432 (7015 ) : 396-401.
  • 8Hamburger A W, Salmon S E. Primary bioassay of human tumor stem cells[J]. Science, 1977, 197(4302):461-463.
  • 9Rnsenblum M L, Gernsa M A, Wilson C B, et al. Stem cell studies of human malignant brain tumors. Part 1:development of the stem cell assay and its potential [J]. J Neurosurg, 1983,58(2) : 170-176.
  • 10巢卫 彭祥鄂.人体肿瘤干细胞软琼脂集落培养—Ⅱ双层琼脂法[J].癌症,1987,6(1):30-30.

共引文献21

同被引文献10

引证文献1

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部