摘要
给Ｗｉｓｔａｒ大鼠灌服复方天棘胶囊溶液，剂量分别为４．０、２．０、０．８ｇ（胶囊）／ｋｇ，连续９０ｄ。结果表明，０．８ｇ（胶囊）ｋｇ组对幼年大鼠的体重增长有明显的促进作用，４．０、２．０、０．８ｇ（胶囊）／ｋｇ组对大鼠造血功能、肝功能和肾功能均无明显毒性作用；组织形态学结果表明，各给药组大鼠的心、肝、脾、肺、肾、胆等重要器官无毒性损害改变。提示大剂量、长期服用复方天棘胶囊无明显毒副作用，是一种毒性低、安全性较大的有效药物。
hree doses of Tian-Ji Capsule Composition(TJCC),4.0,2.0,0.8g/kg(equivalent to 100,50,20times of the clinical dosage)were administered ig 3monthes to three groups of wistar rat respective-ly for long-term toxicological study.The results showed that the body weights in the group of thelowest dosage increased sharply,the hightest dosage increased slowly;otherwise no toxicity was ob-served.Rountine blood examination;hepatic and tenal function were normal compared with controlgroup.In pathological examinations no abnormal changes were fou nd.It indicated that the clinicaldosage of TJCC is safe with no toxic effects
出处
《高原医学杂志》
CAS
1996年第4期21-24,共4页
Journal of High Altitude Medicine
