摘要
目的研究α细辛醚凝胶贴剂的大鼠体外渗透动力学。方法取大鼠离体腹部皮肤,进行体外经皮渗透试验,根据实验结果作渗透曲线。结果透皮速率为63.43μg·cm-2·h-1,时滞(tlag)为7.85h,表观扩散系数(Dm)为9.81×10-4mm2·h-1。结论α细辛醚凝胶贴剂经大鼠皮渗透过程属于零级动力学过程。
AIM To invest the penetration kinetics of the α-asaronurn gel patch in rat. METHODS The transdermal penetrition tests were carried out by the skin of abdomen in rat, in vitro and the penetration curve was drawn according to the result of the test. RESULTS The permeation rate was 63.43 μg· cm^- 2. h^- 1. The lag time was 7.85 h. The apparent diffusion coefficient was 9.81 × 10^-4 mm^2· h^-1. CONCLUSION The penetration process of α-asaronum gel patch in rat skin belongs to zero kinetics.
出处
《中国临床药学杂志》
CAS
2006年第5期318-320,共3页
Chinese Journal of Clinical Pharmacy
