期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

托吡酯对神经元保护作用研究进展 被引量：2

下载PDF
导出
摘要 托吡酯(topiramate,TPM)商品名妥泰,1996年首次应用于临床,目前作为一种新的抗癫药被广泛应用,具有多种抗癫的机制和广泛的药理学特性。除抗癫外还有神经保护、治疗偏头痛、减轻体质量等作用,国内外学者对其神经保护作用和疼痛治疗方面做了大量的临床和试验研究,也对其神经保护和治疗疼痛机制进行了研究。本文重点阐述其神经保护作用,就其研究现状做一综述。
作者 刘新旻 王大斌 邹典定
机构地区 郧阳医学院附属太和医院儿童医疗中心 武汉大学中南医院儿科
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2006年第18期1269-1271,共3页 Journal of Applied Clinical Pediatrics
关键词 托吡酯 神经保护 癫痫 脑损伤
分类号 R96 [医药卫生—药理学]
  • 相关文献

参考文献21

  • 1郭异珍,郑光荣,姚丹.托吡酯联合用药治疗婴幼儿重症癫癎[J].实用儿科临床杂志,2004,19(11):986-987. 被引量：6
  • 2周克英,张蔚,陈霆,杨春何,文飞球.托吡酯长期治疗癫癎的耐受性与安全性[J].实用儿科临床杂志,2004,19(7):579-581. 被引量：7
  • 3Poulsen CF,Simeone TA,Maar TE,et al.Modulation by topiramate of AMPA and kainate mediated calcium influx in cultured cerebral cortical,hippocampal and cebellar neurons[J].Neurochem Res,2004:275-282.
  • 4Rafal M,Kaminski MB,Rogawski MA.Topiramate selectively protects against seizures induced by ATPA,a GluR5 kainate receptor agonist[J].Neuropharmacology,2004,46:1097-1104.
  • 5Rigoulot MA,Koning E,Ferrandon A,et al.Neuroprotective properties of topiramate in the Lithium-Pilocarpine model of epilepsy[J].J Pharmacol Exp Ther,2004,308:787-795.
  • 6Lee SR,Kim SP,Kim JE.Protective effect of topiramate against hippocampal neuronal damage after global ischemia in the gerbils[J].Neurosc Letter,2000,281:183-186.
  • 7Edmonds HL,Jiang YD,Zhang PY,et al.Topiramate as a neuroprotectant in a rat model of global ischemia-induced neurodegeneration[J].Life Sci,2001,69:2265-2277.
  • 8Noh MR,Kim SK,Sun W,et al.Neuroprotecitive effect of topiramate on hypoxic ischemic brain injury in neonatal rats.[J].Exp Neurol,2006[Epub ahead of print].
  • 9Sfaello I,Baud O,Arzimanoglou A,et al.Topiramate prevents excitotoxic damage in the newborn rodent brain[J].Neurobiol Dis,2005,20:837-848.
  • 10Khan SH,Wright SL,Banigesh A,et al.Antiischemic effects of topiramate in a transient global forebrain ischemia model:Neurochemicai,histological,and behavioral evaluation[J].Neurochem Res,2003,28(8):1235-1239.

二级参考文献16

  • 1Angehagen M, Ben-Menachem E, Ronnback L, et al. Novel mechanisms of action of three antiepileptic drugs, vigabatrin, tiagabine, and topiramate[J]. Neurochem Res, 2003,28(2): 333-340.
  • 2Lhatoo SD, Wong IC, Polizzi G, et al. Long-term retention rates of lamotrigine, gabapentin, and topiramate in chronic epilepsy[J]. Epilepsia, 2000,41(12): 1592-1596.
  • 3Mikaeloff Y, de-Saint-Martin A, Mancini J, et al. Topiramate: efficacy and tolerability in children according to epilepsy syndromes[J]. Epilepsy Res,2003,53(3): 225-232.
  • 4Dodson WE, Kamin M, Kraut L, et al. Topiramate titration to response: analysis of individualized therapy study (TRAITS)[J]. Ann Pharmacother,2003,37(5): 615-620.
  • 5Mula M, Trimble MR, Thompson P, et al. Topiramate and word-finding difficulties in patients with epilepsy[J]. Neurology,2003,60(7): 1104-1107.
  • 6Lee S, Sziklas V, Andermann F,et al. The effects of adjunctive topiramate on cognitive function in patients with epilepsy[J]. Epilepsia, 2003,44(3):339-347.
  • 7Coppola G, Capovilla G, Montagnini A, et al. Topiramate as add - on drug in severe myoclonic epilepsy in infany: an Italian multicenter cpen trial[J]. Epilepsy Res, 2002,8: 4945 - 4948.
  • 8胡亚美,江载芳诸福棠实用儿科学[M]第7版,北京:人民卫生出版社,2002:1862-1863
  • 9Coppola G, Caliendo G, Montagnini A, et al. Topiramate in refractory partial-onset seizure in children adolescents and young adults: a multicentric open trial[J]. Epilepsy Res, 2001,43: 255 - 260.
  • 10Mohamed K, Appleton R, Rosenbloom L. Efficacy and tolerability of topiramate in childhood and adolescen. epilepsy: a clinical experience[J]. Seizure, 2002,8,9:137 - 141.

共引文献11

同被引文献21

引证文献2

二级引证文献6

实用儿科临床杂志
2006年 第18期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部