摘要
目的研究类风湿关节炎(RA)患者基质金属蛋白酶3(MMP-3)在血清和关节积液中的表达,探讨其在RA病情活动中的意义。方法选取活动期RA患者,应用酶联免疫吸附测定法测定血清和关节积液MMP-3的水平,综合治疗6个月后再次检测血清MMP-3水平,并与正常对照相比较。结果活动期RA患者血清中MMP-3水平显著高于正常对照组[(67.4±25.8)μg/Lvs(31.7±15.8)μg/L(P<0.01)];关节积液MMP-3水平与血清水平呈正相关(r=0.653,P<0.01);治疗缓解后血清MMP-3水平显著下降[(61.7±23.7)μg/Lvs(38.9±19.1)μg/L(P<0.01)]。结论MMP-3水平与RA的风湿活动及关节滑膜炎相关。
Objective To investigate the level of matrix metalloproteinase-3 （MMP-3） in serum and synovial fluid（SF） derived from patients with rheumatoid arthritis（RA） and to study the mechanism of RA. Methods Serum and SF levels MMP-3 were detected before and after being treated in active RA cases with enzyme-linked immunosorbent assay method, and compared with those normal controls. Results The serum level of MMP-3 was significantly higher（ P〈0.01） in active RA patients than in normal controls, （ 67.4 ±25.8）μg/L vs （31.7±15.8 ）μg/L（ P〈0.01）. There was a positive correlation between MMP-3 levels in serum and SF（ r =0. 653, P〈0.01）. Serum level of MMP-3 decreased in the patients of remission, （61.7±23.7）μg/L vs （38.9±19.1） μg/L （ P G0.01）. Conclusion The levels of MMP-3 in serum and SF were related to the activity and arthrosynovitis of RA.
出处
《临床荟萃》
CAS
北大核心
2006年第19期1389-1390,共2页
Clinical Focus
基金
河北省卫生厅医学科学研究重点课题(编号:03067)
