摘要
目的考察灯盏花素海藻酸钙凝胶小球的制备工艺和最优处方。方法利用滴加法制备凝胶小球,在单因素考察的基础上采用正交设计筛选最优处方。结果最优处方为海藻酸钠质量分数为2.5%,海藻酸钠与药物的比例为1∶1,氯化钙浓度为0.3mol/L。优化处方制备的凝胶小球大小均匀,载药量均匀,包封率和体外释放度具有良好的重现性。结论利用滴加法制备灯盏花素海藻酸钙凝胶小球方法简单。
Objective To investigate the preparation technique and optimal formulation of breviscapin calcium alginate gel beads （BCAGB）. Methods BCAGB was prepared by drop-adding method. Based on the studies of influential factors, optimal formulation was obtained by the orthogonal design. Results The optimal formulation, sodium alginate concentration was 2.5% ratio of alginate sodium to breviscapin was 1：1, and CaCl2 concentration was 0.3 mol/L. Prepared BCAGB in this formulation had such advantages as simple technique, uniformity in diameters, and drug even content with better reproducibility of encapsulated rate and in vitro releasing rate. Conclusion This method is simple for the preparation of BCAGB.
出处
《中草药》
CAS
CSCD
北大核心
2006年第9期1333-1335,共3页
Chinese Traditional and Herbal Drugs
关键词
灯盏花素
海藻酸钙凝胶小球
制备工艺
处方优化
breviscapin
breviscapin calcium alginate gel beads （BCAGB）
preparation technology
formulation optimization
