摘要
【目的】应用自行研制的骨内型牙槽骨牵张器,建立犬垂直向牙槽骨牵张成骨动物模型。【方法】实验动物为中山大学动物中心提供的健康成年杂种犬12只。实验材料为自行设计,纯钛制成的骨内型垂直向牙槽骨牵张器,体部直径3.75mm,长5mm。先拔除犬双侧下颌前磨牙,形成萎缩牙槽嵴的模型。3月后随机选取一侧行骨切开术,植入两枚牵张器。1周后开始牵张,每天1次,每次1mm,共5d;分别在牵张后1、2和3月将动物处死进行临床检查,X线检查和组织学检查。【结果】骨内型垂直牙槽骨牵张器愈合良好。牙槽骨高度平均增加(4.8±0.50)mm。组织学切片显示在牵张区有骨质形成,其骨小梁方向与牵引方向一致。【结论】采用该骨内型牙槽骨牵张器成功建立稳定的、重复性好的犬牙槽骨牵张成骨动物模型,为牙槽骨牵张器的国产化和临床上应用该项技术打下基础。
[ Ohjective ] To establish an experimental dog model of vertical alveolar distraction osteogenesis using intraosseous distractors which were developed hy ourselves. [Methods] Twelve adult Mongrel dogs were providod from the Experimental Animal Center of SUN Yat-sen University. The intraosseous distractors were made in pure Ti ,which were 3.75 mm in diameter and 5 mm in length. The bilateral mandibular premolars were extracted from experimental dogs. After 3 months, an alveolar segmental osteotomy was carried out in the randomly seleetod unilateral atrophy alveolar and two intraosseous vertical alveolar distraetors were placed. After a 7-days latency period, the alveolar bone was augmented at 1.0 mm/d for five days. After a consolidation of 1, 2, and 3 months, the dogs were sacrificed for clinical, radiographic and histological examination. [Results]The intraosseous vertical alveolar distraetors obtained good healing. The atrophy alveolar were augmented for 4.8±0.50 mm. Serial histological sections showed that bone had formed in the distraction zone, where bone trabeculae formed parallel to the tension vector. [Conclusion] A stable and duplieable experimental dog model on study of vertical alveolar distraction osteogenesis have established successfully by the intraosseous distraetors, which provides a good foundation for domestic production of alveolar distraetor and clinical practice of the technique.
出处
《中山大学学报（医学科学版）》
CAS
CSCD
北大核心
2006年第5期566-569,共4页
Journal of Sun Yat-Sen University:Medical Sciences
基金
广东省科技计划重点资助项目(2004B33101010)
关键词
牵张成骨
牙种植
骨内
方法
疾病模型
动物
犬
distraction osteogenesis
dental implantation, endosseous/methods
disease model, animal
dogs
