摘要
目的通过调查获得上海市卢湾区青少年2型糖尿病（T2DM）患病率及相关高危因素。方法对上海市卢湾区12所中学，共10442名（男5319名，女5123名）中学在校生进行晨尿尿糖筛查，对尿糖阳性者进行尿糖复查，并进行空腹血糖及糖耐量试验（OGTT）检查，以确诊糖尿病。对确诊的糖尿病患儿进行糖尿病临床分型诊断，并收集T2DM患儿家族史、出生史、既往史及喂养史等资料。统计上海市卢湾区青少年T2DM患病率并分析其高危因素和基本特征。结果第1次尿糖阳性者为125名，第2次尿糖阳性者为15名；发现T2DM患儿5例，其中男3例，女2例，11～14岁2例，15～19岁3例；随机抽取其中1所中学，同时进行OGTT检查，空腹及2h血糖达糖尿病诊断标准者2例，且与尿糖筛查结果相符；T2DM患病率为47.9／100000，男性为56．4／100000，女性为39．0／100000，各年龄组T2DM患病率：11-14岁为44.1／100000，15～19岁为50．8／100000；筛查出的T2DM患儿抗体检查（谷氨酸脱羧酶抗体、胰岛细胞抗体及胰岛素抗体）结果均阴性；本次筛查出的T2DM患儿体重指数均属肥胖或超重范围，且均有T2DM家族史。结论上海市卢湾区青少年T2DM患病率较高，且随年龄增大呈增高趋势，女性患病率较男性低，肥胖及有糖尿病家族史是青少年T2DM的高危因素。
Objective To investigate the prevalence of type 2 diabetes mellitus and its high risk factors in children and adolescents in Luwan district, Shanghai, Methods Type 2 diabetes mellitus was screened using morning urine among school children aged from 11 to 19 years old in 12 schools（total 10 442 children, 5 319 boys,5 123 girls） in Shanghai, Firstly all the children were screened with a spot morning urine, second round morning urine glucose test and OGT＇F （oral glucose tolerance test） were performed for first urine glucose screen positive children. Results ①125 Children were positive in the first urine-glucose screening and 15 children were positive in the second screening, ②5 Children were diagnosed as type 2 diabetes mellitus, the prevalence rate was 47.9/100 000. ③The prevalence rate of type 2 diabetes mellitus was 56.4/100 000 for boys and 39. 0/100 000 for girls;44, 2/100 000 for those aged 11 to 14 years old and 50. 7/100 000 for those aged 15 - 19 years old. ④ 5 Children diagnosed as type 2 diabetes mellitus were overweight or obesity, and they all had DM family histories. ⑤ Children diagnosed as type 2 diabetes mellitus were a 11 negative in the examination of GADAb,ICA and IAA. Conclusions Our screening program showed that the prevalence rate of type 2 diabetes mellitus in children and adolescents was high. The prevalence rate of type 2 diabetes mellitus was increased with the age,and boys had a higher risk of type 2 DM as compared with girla. Obesity and T2DM family history were the high risk factors for type 2 diabetes mellitus in children and adolescents.
出处
《中国循证儿科杂志》
CSCD
2006年第3期204-209,共6页
Chinese Journal of Evidence Based Pediatrics
基金
复旦大学附属儿科医院院内科研基金资助
关键词
2型糖尿病
患病率
高危因素
青少年
Type 2 diabetes mellitus
Prevalence
High risk factors
Children and adolescents
