期刊文献+

IL-1B及IL-1ra基因多态性与胃癌易患性的相关性研究 被引量:4

Relationship between Interleukin-1B and Interleukin-1 receptor antagonist gene polymorphisms and susceptibility to gastric cancer
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摘要 目的:研究白细胞介素-1(IL-1)B和IL-1受体拮抗剂(IL-1 ra)基因多态性与胃癌易患性的关系。方法:应用基因芯片、聚合酶链式反应(PCR)和PCR-限制性片段长度多态性(PCR-RFLP)技术对65例胃癌患者和71例健康对照IL-1B-31和-511及IL-1 ra基因多态性进行了分析。结果:与对照组相比,胃癌患者IL-1B-31T/T携带者、IL-1B-511C/C携带者显著增加(2χ=6.014,P<0.01;2χ=9.533P<0.001)。其他等位基因或基因型未见差异。结论:胃癌的易患性与IL-1B-31TT和IL-1B-511CC基因型可能有关。 Objective: To study relationship between interleukin-lB gene and interleukin-1 receptor antagonist gene polymorphisms and susceptibility to gastric cancer. Methods: A total of 71healthy controls and 65 patients with gastric cancer were genotyped by gene chip, polymerase chain reaction (PCR) and PCR- restriction fragment length polymorphism (PCR-RFLP) for IL-1 B-31 and -511 single nucleotide polymorphism (SNP) of IL-1B promoter, and IL-1 ra gene 86bp variable number of tandem repeat(VNTR) poly- morphism of IL-1ra gene intron 2(for five different alleles) Results: Comparison of the IL-1B-31TT genotype and -511 CC genotype frequencies showed a significant difference between patients with gastric cancer and healthy controls(χ^2= 6. 014,P 〈 0.01 ; χ^2 = 9. 533 P 〈 0. 001, respectively). No association with patients was found for other investigated polymorphisms in the IL-1 B-31 ,-511 and IL-1 ra genes. Conclusion: The results indicated that susceptibility to patients with gastric cancer was increased in individuals carrying both the IL-1B-31TT and IL-1B-511CC genotype.
出处 《江苏大学学报(医学版)》 CAS 2006年第4期339-341,共3页 Journal of Jiangsu University:Medicine Edition
关键词 白细胞介素-1B IL-1受体拮抗剂 基因多态性 基因芯片 胃癌 interleukin-1 B IL-1 receptor antagonist polymorphism gene chip gastric cancer
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参考文献6

  • 1El-0mar EM,carrington M,Chow WH,et al.Inter1eukin-1 po1ymorphisms associated with increased risk of gastric cancer[J].Nature,2000,404(6776):398-402.
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  • 3杨婕,胡志斌,徐耀初,沈靖,钮菊英,胡旭,郭剑涛,沈洪兵.IL-1B及IL-1RN基因多态性与胃癌易感性的关系[J].世界华人消化杂志,2004,12(8):1769-1773. 被引量:11
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二级参考文献9

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