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双水平气道正压通气治疗COPD合并慢性呼吸衰竭29例

Effect of Nasal Bi-level Positive Airway Pressure on 29 Chronic Obstructive Pulmonary Disease Patients with Chronic Respiratory Failure
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摘要 目的:探讨双水平气道正压通气(BiPAP)对慢性阻塞性肺病(COPD)合并慢性呼吸衰竭的治疗作用。方法:29例COPD合并慢性呼吸衰竭患者应用BiPAP呼吸机进行辅助通气治疗,记录通气前及通气治疗后2 h、12h患者在呼吸室内空气条件下的动脉血气以及肺功能变化。结果:治疗前PaCO2(65±15)mmHg,PaO2(45±15)mmHg,pH(7.28±0.10);FVC(1.25±0.20)L,FEV1(0.65±0.08)L。治疗后2 h,PaCO2(60±13)mmHg,PaO2(75±15)mmHg,pH(7.30±0.12);FVC(1.28±0.18)L,FEV1(0.80±0.10)L。治疗后12 h,PaCO2(58±12)mmHg,PaO2(80±15)mmHg,pH(7.33±0.13);FVC(1.33±0.20)L,FEV1(0.85±0.15)L。治疗前后动脉血氧分压、FEV1比较,差异有统计学意义(P<0.01)。结论:应用BiPAP呼吸机辅助通气治疗COPD合并慢性呼吸衰竭,可提高PaO2,为呼吸衰竭的病因治疗赢得时间。 Objective: To investigate the effect of nasal bi-level positive airway pressure(BiPAP) on patients with chronic obstructive pulmonary disease (COPD) complicated with chronic respiratory failure. Methods: All 29 COPD patients with chronic respiratory failure were treat with BiPAP. The arterial blood gas were analysed and the parameters of lung ventilation function were measured before BiPAP and 2 and 12 hours after treatment. Results: Before BiPAP treatment,the parameters of arterial blood gas and lung ventilation function were PaCO2 (65±15) mmHg,PaO2 (45 ±15) mmHg,pH (7.28±0. 10),FVC (1.25±0. 20) L, FEV, (0. 65±0.08) L,respectively. Two hours after BiPAP, the parameters changed as PaCO2 (60 ± 13) mmHg, PaO2 (75 ± 15)mmHg,pH (7.30±0.12),FVC (1.28±0. 18) L and FEV,(0.80±0. 10) L, respectively. And 12 hours after treatment, the parameters are PaCO2 (58 ± 12) mmHg, PaO2 (80 ± 15) mmHg, pH (7.33±0.13),FVC (1.33±0. 20) L and FEV1(0. 85±0. 15) L. Both the levels of PaO2 and FEV1 had significant changes after the use of BiPAP. Conclusion: Nasal BiPAP may be considered a good treatment option for patients with COPD complicated with chronic respiratory failure due to its good improvement of PaO2 and FEV1.
作者 王先广 朱琥
出处 《武汉大学学报(医学版)》 CAS 2006年第5期664-666,共3页 Medical Journal of Wuhan University
关键词 双水平气道正压通气 慢性阻塞性肺疾病 呼吸衰竭 Bi-level Positive Airway Pressure (BiPAP) Chronic Obstructive Pulmonary Disease (COPD) Respiratory Failure
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