摘要
谷氨酸是中枢神经系统内的重要神经递质,通过与其受体作用,调节正常脑内几乎所有的功能,包括学习和记忆。血管性痴呆是脑血管病引起的获得性智能损害综合征,学习和记忆障碍是其主要表现。许多研究表明,各种谷氨酸受体都与学习和记忆关系密切。因此,谷氨酸受体可能从分子水平上参与了血管性痴呆的发病机制。
Glutamate is an important neurotransmitter in the central nervous system. It regulates almost all functions in normal brain through interacting with its receptors, including learning and memory. Vascular dementia is an acquired syndrome of intelligent damage caused by cerebrovascular diseases. Learning and memory disorders are the major clinical presentation. A number of studies indicate that various glutamate receptors are closely correlated with learning and memory, Therefore, glutamate receptors may have participated in the pathogenesis of vascular dementia at the molecular level.
出处
《国际脑血管病杂志》
2006年第8期623-626,共4页
International Journal of Cerebrovascular Diseases
基金
河北省自然科学基金资助项目(301415)
关键词
谷氨酸受体
长时程增强
学习
记忆
血管性痴呆
glutamate receptor
long-term potentiation
learning
memory
vascular dementia
