摘要
脑出血后脑组织发生一系列病理生理学变化,主要包括血肿扩大、血肿周围代谢异常以及脑水肿形成。近年来的研究表明,铁离子在脑出血后继发性脑损伤中起重要作用,铁螯合剂能够特异性结合铁离子并阻断其介导的损伤过程。文章就脑出血后铁离子的代谢变化、铁离子相关性脑损伤机制以及铁螯合剂的神经保护作用进行综述。
A series of pathophysiologic changes in brain tissues will occur after intracerebral hemorrhage, including the enlargement of hematoma, metabolism abnormality in perihematoma tissues, and formation of cerebral edema. Recent researches have demonstrated that iron ions play an important role in the secondary brain injury after intracerebral hemorrhage. Iron chelator can block iron-induced injury process by specifically binding iron ions. This article reviews the changes of iron metabolism, iron-related mechanisms of brain injury, and the neuroprotective effect of iron chelator.
出处
《国际脑血管病杂志》
2006年第8期630-632,共3页
International Journal of Cerebrovascular Diseases
关键词
脑出血
铁离子
铁螯合剂
氧化损伤
intracerebral hemorrhage
iron ion
iron-chelator
oxidative damage
