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不同剂量阿托伐他汀治疗颈动脉粥样硬化斑块的临床观察 被引量：14

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摘要 目的观察不同剂量阿托伐他汀对老年男性患者颈动脉粥样硬化斑块的消退作用及降脂疗效。方法采用彩色多普勒超声检出颈动脉粥样硬化斑块形成者90例,随机分为两组,分别口服阿托伐他汀10mg、20mg,共16周,观察治疗前后颈动脉内膜中层厚度(IMT)、胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)的变化。结果阿托伐他汀10mg、20mg均能明显消退颈动脉粥样硬化斑块[IMT10mg组治疗后(1.23+0.19)mm比治疗前(1.48+0.26)mm,P<0.05;20mg组治疗后(1.03+0.2)mm比治疗前(1.46+0.23)mm,P<0.05],降低TC、TG、LDL-C水平(P<0.05),升高HDL-C水平。与10mg阿托伐他汀组比较,20mg阿托伐他汀能更进一步降低TC、LDL-C和升高HDL-C水平(P<0.05)。结论阿托伐他汀可消退颈动脉粥样硬化斑块,有效降低血脂水平。
作者 徐军霞 张冬梅 姚俊华 祝梅华
机构地区 福州市南京军区福州总医院干部病房二科 福州市南京军区福州总医院超声影像科
出处 《中华高血压杂志》 CAS CSCD 北大核心 2006年第9期753-754,共2页 Chinese Journal of Hypertension
关键词 颈动脉粥样硬化斑块 阿托伐他汀 血脂
分类号 R543.5 [医药卫生—心血管疾病]
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参考文献4

  • 1[1]Grundy SM,Clemen JL,Mers CN,et al.Implication of recent clinical trials for the national cholesterol education program adult treatment panel Ⅲ guideline[J].Circulation,2004,110:227-230.
  • 2杜书章,岳晓红,杨国杰,张晓坚,康建.阿托伐他汀治疗高血压患者动脉粥样硬化[J].医药论坛杂志,2006,27(8):17-18. 被引量：23
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  • 4[4]Downs JR,Clearfield M,Whitney E,et al.Primary prevention of acute coronary events with lovastatin in men and women with average choresterol levels[J].JAMA,1998,1615-1622.

二级参考文献8

  • 1Grundy SM,Clemen JI,Mers CN,et al.Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel Ⅲ guideline,Circulation,2004,110(2):227
  • 2Cannon CP,Braunwald E,McCabe CH,et al.Intensive versus Moderate lipid lowering with statins after acute coronary sysdromes.N Engl Med,2004,350(15):1495
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  • 5Roivainen M,Kajander MV,Palosuo P,et al.Infections,Inflammation,and the Risk of Coronary Heart Disease.Circulation,2000,101:252
  • 6Downs JR,Clearfield M,Whitney E,et al.Primarg prevention of acute coronary events with lovastatin in men and womem with average choresterol levels.JAMA,1998:1615-1622
  • 7Ridker PM,Buring JE,Shih J,et al.Prospective Study of C -Reactive Protein and the Risk of Future Cardiovascular Events Among Apparently Healthy Women.Circulation,1998,98:731
  • 8Crisby M,Fredriksson GN,Shah PK,et al.Pravastatin Treatment Increases Collagen Content and Decreases Lipid Content,Inflammation,Metalloproteinases,and Cell Death in Human Carotid Plaques:Implications for Plaque Stabilization.Circulation,2001,103:926

共引文献22

同被引文献112

引证文献14

二级引证文献66

中华高血压杂志
2006年 第9期

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