摘要
目的探讨肾功能不全对心力衰竭预后的影响。方法根据肾功能将心力衰竭患者分为心肾综合征组70例和单纯心力衰竭组131例,观察其治疗和预后情况。结果心肾综合征组与单纯心力衰竭组相比,年龄、血肌酐、水肿发生率,糖尿病和高血压患病率及住院天数显著增高(P<0.05或0.01),血红蛋白浓度显著降低(P<0.01);而2组间性别、心力衰竭时间、心功能、冠心病及高脂血症的患病率差异无显著性。随访心肾综合征组生存率明显低于单纯心力衰竭组(P<0.001),在成功应用血管紧张素转换酶抑制剂的患者中也有类似关联。Cox回归模型分析显示,心功能分级、射血分数、血肌酐水平和血红蛋白浓度与心力衰竭死亡独立相关。结论肾功能不全明显增加心力衰竭病死率。
Objective To examine the prognostic implications of renal insufficiency in patients with heart failure. Methods Based on renal function, the patients with heart failure were divided into cardiorenal syndrome group （ n = 70 ） and single heart failure group （ n = 131 ）. The treatment and prognosis was observed. Results Compared with single heart failure patients, the cardiorenal syndrome group had higher age, serum creatinine, edema rate, hospital stay days, and prevalence of hypertension and diabetes mellitus（ P 〈 0.05 or P 〈 0.01 ） but lower hemoglobin （P 〈 0.01 ）. However, sex, duration of heart failure, cardiac function, and prevalence of coronary disease and hyperlipidemia had no statistically difference between groups. Patients with cardiorenal syndrome had lower survival rate than those of single heart failure group （ P 〈 0.01 ）. The similar correlation was found in the patients with angiotensin-converting inhibitor agents. Cox multivariate analysis demonstrated that renal insufficiency was associated with cardiac classification ,ejection fraction, serum creatinine and hemoglobin levels. Conclusion Renal insufficiency is apparently correlated with an increased risk of mortality in patients with heart failure.
出处
《中国综合临床》
北大核心
2006年第11期977-979,共3页
Clinical Medicine of China
关键词
心力衰竭
肾功能不全
心肾综合征
Heart failure
Renal insufficiency
Cardiorenal syndrome
