摘要
采用逆相蒸发法制备稳定的白细胞介素２（ＩＬ－２）大单层脂质体，对其包封率、稳定性进行了测定。建立Ｃ５７ＢＬ／６小鼠荷瘤动物模型，通过给荷瘤小鼠腹腔注射空白脂质体、单纯ＩＬ－２及ＩＬ－２脂质体来比较其在肿瘤生长中的抑制作用。结果是空白脂质体组抑瘤率为４．３％，单纯ＩＬ－２和脂质体ＩＬ－２的抑瘤率分别为３４．０％和５４．６％。空白脂质体组与单纯对照组相比差异无显著性（Ｐ＞０．０５），脂质体ＩＬ－２组与单纯ＩＬ－２组之间差异有显著性（Ｐ＜０．０５），脂质体ＩＬ－２的抑瘤率比单纯ＩＬ－２抑瘤率提高了２０．６％。
Human recombinant interleukin-2(IL-2)was encapsulated in liposomes by reverse-phare evaporation method with an encapsulation efficiency of 34.5%±1.1%,and the antitumor effects of the liposomes containing IL-2 were studied using the C57BL/6 mice with Louis lung carcinoma as an experimental model.The iv.injection of IL-2 liposome (5 333 U/g for the IL-2 dose) significantly inhibited the tumor growth as determined from the mean tumor weight (P<0.05). The inhibition rate of IL-2 liposome was increased by 20.6% compared with free IL-2.
出处
《实用肿瘤杂志》
CAS
北大核心
1996年第5期227-229,共3页
Journal of Practical Oncology
