摘要
目的研究血栓调节蛋白(TM)在肾盂移行细胞癌及肾细胞癌中的表达及临床意义。方法选择40例不同分期、不同分级的肾盂移行细胞癌及20例不同分期、不同分级的肾细胞癌标本,应用免疫组织化学SP法研究TM的表达。结果40例肾盂移行细胞癌,TM表达者37例(92.5%),20例肾细胞癌,TM表达1例(5%),其两组表达率明显不同(P<0.01)。肾盂移行细胞癌组织TM表达阳性细胞百分数随病理分级、临床分期的上升而下降(P<0.01或P<0.05)。另外TM表达阴性者再发膀胱癌发生率为66.7%,TM表达细胞百分数小于41.7%的患者中再发膀胱癌发生率为62.5%,TM表达细胞百分数大于41.7%的患者中再发膀胱癌发生率为3.4%,前两者与后者相比,其再发膀胱癌发生率明显升高(P<0.01)。结论TM表达量与肾盂移行细胞癌的恶性程度、病程情况等生物学行为有关。TM表达阴性及TM表达阳性细胞百分数小于41.7%的肾盂移行细胞癌再发膀胱癌可能性大,应对此类肾盂移行细胞癌患者术后按膀胱肿瘤对待。TM可以作为一种瘤标来鉴别诊断肾盂移行细胞癌与肾细胞癌。
Objective To study the expression of thrombomodulin （TM） in renal pelvic transitional cell carcinoma and in renal cell carcinoma. Methods 40 cases of renal pelvic transitional cell carcinoma and 20 cases of renal cell carcinoma in different stages and classification were studied by the means of SP immunohistochemistry. Results There were 37（92.5%） positive cases in the 40 cases of renal pelvic transitional cell carcinoma, and 1 positive case （5%） in the 20 cases of renal cell carcinoma. The TM positive rates were significantly different between the two groups（P〈0.01）. The TM positive cell rate decreased with the procession of stages and classification in transitional cell carcinoma（P〈0.01 or P〈0.05）. In addition, the recurrence of bladder carcinoma was 66.7% in the TM negative cases. In the cases whose TM expression was less than 41.7% and in the cases whose TM expression was more than 41. 7%, the recurrence rate was 62. 5% and 3. 4% respectively. Compared with the latter group, the recurrence rate was significantly higher in the former two groups. Conclusion The TM positive cell rate decreased with the procession of stages and classification in transitional cell carcinoma, and therefore tumor malignant degree and prognosis could be indicated by the TM expression. Bladder carcinoma was more likely to recur in patients with TM negative and TM positive cell rates less than 41. 7%, and therefore those patients should be treated as bladder carcinoma after operation. TM could be a marker of carcinoma that could differentially diagnose renal pelvic transitional carcinoma from renal carcinoma.
出处
《现代泌尿外科杂志》
CAS
2006年第5期252-254,共3页
Journal of Modern Urology
关键词
肾盂移行细胞癌
肾细胞癌
血栓调节蛋白
renal pelvic transitional cell carcinoma
renal cell carcinoma
thrombomodulin
