摘要
为探讨宫颈湿疣的诊断及其与宫颈癌发生的关系，作者对４８例宫颈湿疣、４６例宫颈癌进行了细胞学、组织病理学、阴道镜、免疫组化及ＨＰＶ—ＤＮＡ相关序列及超微结构检查。细胞学诊断宫颈湿疣的阳性率为７０．８３％。３９例外阴、阴道尖锐湿疣中，２１例经阴道镜检查并活检证实有宫颈湿疣。单纯宫颈湿疣免疫组化检查ＨＰＶ抗原的检出率为６３．１５％。宫颈湿疣及宫颈癌ＨＰＶ—ＤＮＡ基因相关序列的检出率分别为４２１％及８５％。依靠细致的妇科检查，对外阴、阴道湿疣及宫颈刮片异常的患者常规作阴道镜检查及其引导下的宫颈活检，不难作出宫颈湿疣的诊断。
8 cases of cervical condyloma(CC)and 46 cases of cervical carcinoma were studied toinvestigate the accuracy of different methods in diaguosis of CC and the relationship between CCand cervical carcinoma Papillomavirus infections were detected by means of cytologicalsmears, colpocopic and pathologic examinations,imunohistochemistry, electron microscopic ex-amination and Southern blot DNA hybridization The detection rate of CC by smears withkoilocytosis was 70.83%.39 cases of vular &/or vaginal condylomata were diagnosed in the periodof this study and by colposcopic,pathologic examination。21 cases proved to have CC。Byimmunohistochemistry,HPV-Ag was detected in 63.15%of simple CC.HPV-DNa sequences weredetected in 42.1%of CC and 85% of cervical cancers.Routine colposcopic examination and biopsyshould be taken for patients with vulvar&/or vaginal condyloma and those with abnormalcervical smears.
出处
《重庆医科大学学报》
CAS
CSCD
1996年第3期229-233,共5页
Journal of Chongqing Medical University
关键词
乳头瘤病毒
宫颈湿疣
宫颈肿瘤
Human papillomavirus infection
Cervical condyloma
Carcinoma of uterinecervix
