摘要
目的:探讨居住海拔4300m高原不同时间青年肝功能、肾功能、血脂、血浆蛋白及血清酶的变化。方法:对进驻高原3个月(n=174)、6个月(n=73)及一年(n=88)的男性汉族青年检测其血清总胆红素(STB)、直接胆红素(SDB)、总蛋白(TP)、白蛋白(ALB)、尿素氮(BUN)、肌酐(Cr)、尿酸(UA)、甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、丙氨酸氨基转换酶(ALT)、门冬氨酸氨基转换酶(AST)、γ-谷氨酰转移酶(γ-GT)、碱性磷酸酶(ALP)。结果:居住3个月较6个月及1年STB、SDB、BLA、TC、TG、LDL-C、γ-GT增高,差别有显著性(P<0.05或0.01),3个月较1年AST、ALT、BUN增高,差别非常有显著性(P<0.01);居住6个月较1年TP增高,差别有显著性(P<0.05);其余均无统计学意义(P>0.05)。结论:进驻高原初期引起肝功能、肾功能等多项指标异常,脏器损伤较居住半年以上严重。
Objective： To explore the function of liver and kideny and changes on level of blood fats, plasma protein and serum enzyme in youth stayed at 4 300m altitudes for different period. Methods： Level of serum total bilirubin（STB）, serum direct bilirubin（SDB）, total protein（TP）, albumin（ALB）, blood urea nitrogen（BUN）, creatinine（Cr）, uric acid（UA）, triacylglycerol（TG）, total cholesterol（TC）, high density lipoprotein cholesterol （ HDL - C）, low density lipoprotein cholesterol （LDL - C）, alanine aminotransferase（ALT）, aspartate aminotransferase（AST）, γ- glutamyl transferase（γ- GT） and alkalinephosphatase（ALP） were measured in three healthy youth groups： they were exposed to 4 300m altitudes for 3 months （n = 174）, 6 months （n = 73） and 12 months （n = 88） respectively. Results： The level of STB,SDB,BLA,TC,TG,LDL--C and γ--GT were increased in 3 months exposed group compared with that 6 months and 12 months group （P〈0.05 or P〈0.01）. The level of AST, ALT, BUN and TP were increased in the 6 months group compared with that 12 months group （P〈0.05 or 0.01）. Other index had not significant differences （P〉0.05）. Conclusions： The functional indexes of liver and kidney in healthy youths who exposed early to high altitude have more abnormal changes than those people exposed to altitude longer.
出处
《高原医学杂志》
CAS
2006年第3期5-7,共3页
Journal of High Altitude Medicine
关键词
高原
肝功能
肾功能
血脂
酶
High altitude
Liver funetion
Renal funetiom Blood fats
Enzyme
