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萘普生有色片含量和有关物质测定方法的建立 被引量:1

Determination of Content of Naproxen and its Related Substances in Naproxen Colored Tablets by HPLC
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摘要 目的:建立同时测定萘普生的含量及有关物质的高效液相色谱法。方法:色谱柱采用C18柱(ZORBAX C18 14.6mm×150mm,5μm),流动相为乙腈-水-冰醋酸(50:49:1),检测波长为254nm。结果:本法的平均回收率为94.9%,相对标准偏差为0.15%,在5—45μg/ml的浓度范围之间呈线性。结论:本法可同时测定萘普生含量及其有关物质含量,且简便、灵敏、准确。 Objective: To develop a HPLC method for determination of content of naproxen and its related substances in naproxen colored tablets. Method: The separation was performed on a ZORBAX C18 Cohunn (4.6 mm ×150mm,5μm) with acet onitrile-water-glacial acetic acid (50: 49: 1 ) as mobile phase. The detection wavelength was set at 254 nm . Result: The average recovery of naproxen using this method was 94.9%. RSD was 0.15% .Results of this method showed linear correlation in the range of 5 - 45μg/ml. Conclusion: The HPLC method developed is simple, sensitive and accurate. It can be used for determination of content of naproxen and its related substances in naproxen colored tablets.
出处 《药学进展》 CAS 2006年第9期422-424,共3页 Progress in Pharmaceutical Sciences
关键词 萘普生 高效液相色谱法 含量 有关物质 Napmxen HPLC Content Related substance
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