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核黄素对烧伤后早期损害的防治作用 被引量:5

Study of effects of riboflavin on systemic damages in early stage postburn in rats
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摘要 采用大鼠30%Ⅲ度烧伤模型,伤后立即予以腹腔注射核黄素,通过尿量、动物死亡率统计、血浆丙二醛、血清皮质醇、尿儿茶酚胺以及血容量和不同组织器官微血管通透性的观察测定,并以单纯烧伤和正常动物作对照,结果显示:①核黄素治疗后烧伤动物休克期尿量始终高于未治疗的单纯烧伤组;②治疗后的动物血浆丙二醛含量明显下降;③治疗组血清皮质醇水平和尿肾上腺素含量相对稳定;④血浆和组织伊文思蓝-蛋白质含量的测定结果,治疗组血浆、肝、肾以及痂下组织的伊文思蓝-蛋白质浓度均低于单纯烧伤组;⑤治疗组伤后24h存活率显著高于单纯烧伤组。提示烧伤早期核黄素的运用能维持相对较充足的血容量;同时减轻机体伤后剧烈的应激反应和机体脂质过氧化损害; After the rats were inflicted with 30% TBSA full thickness burns, they were intraperitoneally injected with riboflavin and then blood and urine volume, level of urine riboflavin, plasma malondialdehyde, serum cortisol and urine catecholamines, and microvascular permeability of various tissues and organs were determined. Those of the normal rats and burnt rats without riboflavin treatment were determined likewise to serve as the negative and positive controls. The findings were as follows: (1) The urine volume was higher in the riboflavin treated rats than in those without treatment in the shock stage ( P <0.01). (2) The plasma malondialdehyde level was significantly lower in the riboflavin treated rats. (3) The level of plasma cortisol and urine epinephrine were maintained relatively stable in the treated rats. (4) The Evans blue protein content in the plasma, liver, kidneys and subeschar tissues was lower in the treated rats than in those without treatment. (5) The survival rate of the burnt rats in the 24th hour postburn was significantly higher in the treated rats than in those without. These findings suggest that the administration of riboflavin in the early stage postburn can maintain a reasonably sufficient blood volume and prevent drastic stress reaction and lipid peroxidation from occurring. Consequently, the survival rate of the rats is improved.
出处 《第三军医大学学报》 CAS CSCD 北大核心 1996年第5期387-389,共3页 Journal of Third Military Medical University
关键词 烧伤 核黄素 应激 防治 burns riboflavin stress lipid peroxidation shock rat
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  • 1曹履先,陈虎,江岷,胡亮钉,曾堂清,刘惠兰.同种异基因骨髓移植治疗白血病的临床研究[J].山西白血病,1992,1(4):208-213. 被引量:2
  • 2Mulherin DM, Thumham DI, Situnayake-RD, et al. Glutathione reductase activity, riboflavin status, and disease activity in rheumatoid arthritis. [J]. Ann Rheum Dis, 1996,55( 11 ) :837 - 840.
  • 3Shoffner JM, Wallace DC. Oxidative phosphorylation diseases and mitochondrial DNA mutatiocs: diagnosis and treatment[J]. Annu Rev Nutr, 1994,14: 535 - 568.
  • 4Kerr DS. Protean manifestations of mitochondrial diseases: a minireview[J] .J Pediatr Hematol Oncol, 1997,19(4) :279- 286.
  • 5Ave'yanov AA, Lapikova VP, Nikolaev ON, et al. Active oxygenassociated control of rice blast disease by ~riboflavin and roseoflavin[J]. Biochemistry (Mosc), 2000,65(11):1292- 1298.
  • 6Helveston W,Cibula JE,Hurd R, et al. Abnormalities of antioxidant metabolism in a case of Friedrelch's disease[J]. Clin Neuropharmacol, 1996, 19(3) :271 - 275.
  • 7Morris AA, Leonard JV. The treatment of congenital lactic acidoses[J]. J Inherit Metab Dis, 1996,19(4): 573-580.
  • 8Kodentsova VM, Vrzhesinskaia OA, Trofimenko-EV, et al. Metabolism of some vitamins in children with insulin-dependent diabetes mellitus: importance of the disease duration, severity and metabolism impairment[J] . Vopr Med Khim, 1994,40(4):33-38.
  • 9Novikov DA, Provotorov VIa, Khabarov AA, et al. The demonstration of a hepatitis syndrome by an index of vitamin B2 excretion.[J].Voen Med Zh, 2000,321(6):65-67.
  • 10Skoupy S, Fodinger M,Veitl M, et al. Riboflavin is determinant of total homocysteine plasma concentrations in end-stage renal disease patients[J]. J Am Soc Nephrol, 2002,13(5):1331 - 1337.

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