摘要
以大鼠条件性回避反应的习得作为学习的指标，观察了海马内注射ＡＣＴＨ的促学习作用，以及海马内注射β受体阻断剂普萘洛尔对这一作用的拮抗效应。结果如下：（１）ＡＣＴＨ组（０．２ＩＵ／２μｌ，ｉｈ）和生理盐水组（２μｌ，ｉｈ），随着训练，条件性回避反应的习得率呈逐日上升的现象，尤以ＡＣＴＨ组更为显著（Ｐ＜０．０５～０．０１）；（２）普萘洛尔（０．１ｍｇ／２μｌ，ｉｈ）有显著拮抗ＡＣＴＨ易化条件性回避反应的作用（Ｐ＜０．０１～０．００１）。由此表明，ＡＣＴＨ通过海马起促学习作用，海马中去甲肾上腺素能系统β受体介入了这一促学习过程。
The antagonizing effects of intrahippocampally injected propranolol on ACTH facilitated learning acquisition was observed when the conditioned avoidance response in a shuttle box was employed as an index of acquistion of learning in rats. It was found that: (1) The learning rate of the conditioned avoidance response gradually increased with the prolongation of daily behavioral training in a shuttle box and the increasing speed of the animals in ACTH injected group was significantly higher than that in the control; (2) The ACTH facilitated acquisition of conditioned avoidance response was significantly antagonized by propranolol (0.1 mg/μl) ( P <0.01～0.001). Our findings suggest that the hippocampus is an important site for the ACTH facilitated learning and beta adrenoceptors in the hippocampus participate in the ACTH facilitated learning acquisition.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1996年第4期338-339,共2页
Journal of Third Military Medical University
关键词
回避反应
海马
学习
ACTH
普萘洛尔
conditioned avoidance response
adrenocorticotrophin (ACTH)
propranolol
hippocampus
learning
rat
