摘要
目的:对有活性的茜草氯仿提取部位进行化学成分的分离筛选。方法:首次利用DPPH(1,1-d iphenyl-2-p icrylhydrazy)方法,对茜草提取部位进行抗氧化筛选。结果:从有活性的氯仿部位分离得到11个化合物,经波谱分析鉴定为Mollugin(1),Furomollugin(2),6-hydroxyrub iad in(3),A lizarin(4),6-m ethxylqu in izarin(5),1-hy-droxy-2-m ethylanthraqu inone(6),Xanthopurpurin(7),Anthragallol(8),Rub iad in(9),Ursolic ac id(10),β-sitos-terol(11)。结论:其中化合物3,4,8具有抗氧化活性,化合物10为首次从该属中分离得到。
Objective： The active chlorofrom extract from rubic cordifolia was isolated. Methods： The extracts of Rubia cordifolia were tested by the method of DPPH scavenging free radical for the first time. Results： From the active chloroform extract, eleven compounds, Mollugin （1）, Furomollugin （2）, 6 - hydroxyrubiadin （3）, Alizarin （4）, 6 - methxylquinizarin （5）, 1 - hydroxy - 2 - methylanthraquinone （6）, Xanlhopurpurin （7）, Anthragallol （8）, Rubiadin （9）, Ursolic acid （10）,β -sitosterol （11）, were isolated. Conclusion： Compound 3, 4 and 8 had antioxidant activity, EC50 was 14.7, 2.8, 13.3 μg/ml respectively, compound 10 was isolated for the first time from the genus.
出处
《河南大学学报（医学版）》
CAS
2006年第3期6-8,共3页
Journal of Henan University:Medical Science
基金
国家自然基金项目(30500646)
中国博士后科学基金(20040352254)
