摘要
为了探讨基因MMP-2、PTEN和FN与胃癌临床病理因素的关系,采用免疫组织化学方法,检测了56例胃癌中MMP-2、PTEN和Fn的表达.结果表明:MMP-2、PTEN的阳性表达和Fn的异常表达分别为58.9%、55.4%和60.7%.低分化癌中MMP-2的表达和Fn的异常高于高分化癌(P<0.05).MMP-2的表达和Fn的异常与胃癌浸润深度、淋巴结转移正相关(P<0.05),PTEN的表达与淋巴结转移负相反(P<0.05).MMP-2和PTEN的表达呈负相关(P<0.05),MMP-2表达和Fn的异常呈正相关(P<0.01),PTEN表达与Fn异常之间无明显相关性(P>0.5).通过该研究发现,检测胃癌组织中MMP-2、PTEN和Fn的表达,有助于了解胃癌的发展和评估胃癌患者的预后.
In order to explore the relationship between genes MMP-2, PTEN, Fn and the clinicopathological factors in gastric cancer, the expression of MMP-2, PTEN and Fn were investigated in 56 cases of gastric cancer tissues bv immunohistological method. The results indicated that, in gastric cancer, the expression of MMP-2, PTEN and abnomal Fn were 58.9%, 55.4% and 60. 7% respectively . The expression rates of MMP-2 and abnomal Fn were higher in poor differentiated cancer than that in well differented cancer（ P〈 0.05） . The expression of MMP-2 and abnomal Fn correlated positively to the invasion depth, lymph node metastasis（P〈0.05）, the expression of PTEN correlated negatively to lymph node metastasis（ P 〈 0.05） . There was a negative relationship between the expression of MMP-2 and PTEN , and a positive relationship between the expression of MMP-2 and Fn , and no relationship between the expression of PTEN and Fn. Results showed that the expression of MMP-2, PTEN and Fn in gastric cancer can help us to understand the development of gastric cancer and patient＇s prognosis.
出处
《生命科学研究》
CAS
CSCD
2006年第3期265-269,共5页
Life Science Research
