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天麻素分散片的制备及稳定性研究 被引量:1

Preparation and Stability Investigation of Gastrodin Dispersible Tablets
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摘要 以崩解时限为指标,采用正交试验设计优化最佳处方,制备天麻素分散片,通过初步稳定性试验评价该制剂的质量。结果表明,L-HPC和CMS-Na两种崩解剂采用内外加法联合使用效果最优,最佳处方崩解时间为106 s,体外溶出百分率明显高于普通片,初步稳定性试验表明制剂质量稳定。 To prepare and optimize the gastrodin dispersible tablets by orthogonal design using the disintegration time as index. The quality of gastrodin dispersible tablets was evaluated by the initial stability test. The results showed that the disintegration time of optimized prescription formulation was 106s,i. e L-HPC and CMS-Na was used by combining exterior and interior and the dissolution percent in vitro was obviously super to the conventional tablets. Moreover, the quality of the dispersible tablets was very well by stability test.
出处 《中药材》 CAS CSCD 北大核心 2006年第9期970-973,共4页 Journal of Chinese Medicinal Materials
关键词 天麻素 分散片 正交设计 崩解时限 Gastrodin Dispersible tablets Orthogonal design Disintegration time
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