摘要
大鼠等客心脏制备经低血流缺血（０．２ｍｌ／ｍｉｎ）６０ｍｉｎ后复灌３０ｍｉｎ。组（２）灌注液中镁浓度始终为１．２ｍｍｏｌ／Ｌ，而组（３）及组（１）则于缺血期分别换用１５ｍｍｏｌ／Ｌ或无镁灌注液。结果表明，高镁对心肌线粒体Ｃａ^（２＋）－ＡＴＰ酶活性、合成ＡＴＰ能力具明显保护作用，并减轻了钙超载现象，部分地防止缺血后再灌注损伤。
Isovolumic rat heart preparations were exposed to low flow ischemia (0. 2 ml/ min) for 60 min, followed by 30 min of reperfusion. The concentration of Mg(2+) was maintained 1. 2 mmol/L throughout the study in group 2, while increased to 15 mmol/ L or depleted to zero during ischemia only in group 3 and group 1 respectively. High concentration Mg(2+) showed a significantly protective effect on Ca-ATPase activity and synthesis ability of ATP in myocardial mitochondria, and decreased its calcium overload. Thus it appears that high concentration Mg(2+)infusion may partially reverse positschemicreperfusion injury to heart.
出处
《生理学报》
CAS
CSCD
北大核心
1996年第3期303-306,共4页
Acta Physiologica Sinica
基金
国家科委及卫生部资助
关键词
心肌缺血
镁
再灌注
线粒体
magnesium
myocardial ischemia
reperfusion
calcium
mitochondria
