摘要
用结扎颈动脉和缺氧的方法建立一侧缺氧缺血性脑损伤(HIE)动物模型,观察脑活素对HIE大鼠脑组织损伤的治疗作用。结果发现,缺氧缺血后新生大鼠脑组织血栓素B2(TXB2)和6酮--前列腺素F1α(6-keto-PGF1α)含量、细胞凋亡数及对侧脑组织含水量均显著升高,表明新生大鼠缺氧缺血性脑损伤与脑血流改变、脑细胞凋亡及脑组织含水量的变化密切相关;缺氧缺血大鼠应用脑活素治疗后,其脑组织TXB2和6-keto-PGF1α含量、细胞凋亡数及脑组织含水量均下降,表明脑活素通过改善脑血流、降低脑细胞凋亡及脑水肿程度来减轻缺氧缺血造成的损伤,对新生大鼠缺氧缺血性脑损伤发挥有效的治疗作用。
To measure the effect of cerebrolysin on damages of brain tissues in newborn rat, the hypoxic-ischemic encephalopathy （HIE） model was established. The result showed that the content of thromboxane B2 （ TXB2 ） and 6-keto-prostaglandin F1α （ 6-keto-PGF1α ） , the number of apoptosis cell and the content of water increased significantly in brain tissue of hypoxic-ischemic newborn rats as compared with those of control groups, indicating that the changes of brain blood, apoptosis and in brain edema participated in brain damages of hypoxic-ischemic encephalopathy in newborn rat. After the treatment with cerebrolysin, the content of TXB2 and 6-keto-PGF1α the number of apoptosis cell and the content of water decreased as compared with those of HIE group. The results indicated that cerebrolysin had treatment effects on hypoxic-ischemic encephalopathy in newborn rat by improving brain blood, reducing number of apoptosis cell and brain edema.
出处
《畜牧与兽医》
北大核心
2006年第7期17-20,共4页
Animal Husbandry & Veterinary Medicine
基金
黑龙江省科技攻关计划(GP7C21-1)
关键词
缺氧缺血性脑损伤
脑活素
新生大鼠
hypoxic-ischemic encephalopathy
cerebrolysin
newborn rat
