摘要
目的：探讨三维适形放射治疗局部晚期胰腺癌的临床价值。方法：52例局部晚期胰腺癌经临床确诊不能手术患者采用三维适形同中心铅挡块放射治疗。肿瘤最大径小于5cm，单次剂量5～8Gy，隔日1次，DT45～56Gy；肿瘤最大径大于5cm，单次剂量2．5～3Gy，每日1次，DT55～60Gy。结果：放疗后3～6个月行CT复查，CR20％（10／50），PR58％（29／50），NC18％（9／50），PD8％（4／50），总有效率（CR＋PR）78％（39／50）。腹痛缓解率82％（23／28），黄疸消退率83％（10／12），1年生存率64％，2年生存率16％。副反应主要为轻度的胃肠道反应，表现为恶心、呕吐、腹泻；16例出现血象下降；2例放疗后出现十二指肠溃疡；1例出现肠梗阻。结论：三维适形放射治疗局部晚期胰腺癌姑息止痛效果好，退黄作用快，毒副反应轻，能延长生命，提高生活质量。
Objective：To investigate the value of three dimensional conformal therapy （3D-CRT） on the local advanced pancreatic carcinoma. Methods：52 patients with local advanced pancreatic carcinoma received conformal radiotherapy. The patients with tumor diameter smaller than 5cm received 5 -8Gy per day, once in two days, to a total close of 45 -56Gy. The others were treated with 2. 5 ～ 3Gy per day, 5d per week, to a total close of 55 -60Gy. Results：All patients completed the radiotherapy except two patients died of aggravated disease. CT examination was performed in the 3 to 6 month followed-up period to verify the therapeutic effects. The local effects in 50 patients were： CR 20% （10/50） ,PR 58% （29/50） ,NC 18% （9/50） ,PD 8% （4/50）. Total effective rate （ CR ＋ PR） reached 78% （39/50）. the abdominal pain relief rate was 82% （23/28） , 10 of the 12 patients had jaundice reduced obviously after treatment. The one year and two years survival rates were 64% and 16%. the most side effect was GI reaction, and leucopenia was observed in 16 patients, duodenal ulcer observed in 2 patients. Conclusion：h is an effective approach to improve life quality and prolong survival time for unresectable pancreatic carcinoma.
出处
《临床肿瘤学杂志》
CAS
2006年第9期698-699,702,共3页
Chinese Clinical Oncology
