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穿透支原体脂质相关膜蛋白诱导人单核细胞产生炎症性细胞因子 被引量:5

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摘要 穿透支原体(M.penetrans,Mpe)是从感染人类免疫缺陷病毒的患者球液中分离出来的,被称为艾滋病相关支原体。Mpe能依靠其特殊的顶端结构黏附和入侵宿主的红细胞、CD4^+T细胞和巨噬细胞等,但关于其对宿主的致病性及其可能的致病机制还不十分清楚。脂质相关膜蛋白(LAMPs)是暴露在Mpe表面与周围环境各种成分不断相互作用因而影响机体的免疫系统的一种主要蛋白。我们的研究证实,Mpe LAMPs能诱导小鼠巨噬细胞表达诱导性一氧化氮合酶和产生一氧化氮。
出处 《中华传染病杂志》 CAS CSCD 北大核心 2006年第4期251-253,共3页 Chinese Journal of Infectious Diseases
基金 湖南省自然科学基金项目(02JJY2025)
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