摘要
目的:探讨HER-2和COX-2在乳腺癌组织中的表达及其意义。方法:构建乳腺癌组织微阵列,应用免疫组织化学SP法检测160例乳腺浸润性导管癌患者HER-2和COX-2的表达。结果:乳腺癌组织中HER-2和COX-2的阳性表达率分别为35%(56/160)和55·6%(89/160),且HER-2和COX-2的表达均与组织学分级、淋巴结转移、雌激素受体、孕激素受体及无病生存期显著相关,P<0·05或P<0·01;COX-2与HER-2的表达密切相关,P<0·01。结论:HER-2和COX-2的表达与乳腺癌的生物学行为有关,同时检测HER-2和COX-2可能对乳腺癌预后的判断及靶向治疗的选择提供帮助。
OBJECTIVE： To investigate HER-2, COX-2 expressions and evaluate their significance, in human breast cancer. METHODS： HER-2 and COX-2 expressions were detected in 160 samples of breast invasive ductal carcinomas with the immunohistochemically performing tissue microarray （TMA） technology. RESULTS： HER-2 and COX-2 was overexpressed in 55.6% （89/160） and 35%（56/160） separately of breast carcinomas. Increased HER-2 and COX-2 expressions corresponded to histological grading, lymph node metastasis, ER state and PR state （P〈0. 05 or P〈0.01）, and disease-free survival, P〈0. 01. A significant association between HER-2 and COX-2 expressions was observed, P〈0. 01. CONCLUSIONS： Both HER-2 and COX-2 expressions are significantly associated with the biological behavior of human breast cancer, and might therefore be useful prognostic indicators as well as targets for therapy.
出处
《中华肿瘤防治杂志》
CAS
2006年第17期1317-1320,共4页
Chinese Journal of Cancer Prevention and Treatment
基金
山东省科技发展计划项目(2002BB1BCB4)
