摘要
目的:观察巴曲酶联合苯那普利、雷公藤多甙治疗IgA肾病(IgA nephroputhy,IgAN)的效果。方法:将84例Lee氏分级≥Ⅲ级伴肾功能不全的IgAN患者随机分为两组:巴曲酶、苯那普利、雷公藤多甙三联组(BBT三联组)及苯那普利组,观察两组的疗效。结果:①6个月后,BBT三联组Bun、Scr均有一定程度下降(前者P<0.01,后者P<0.05),疗效优于苯那普利组。②6个月后,BBT三联组24 h尿蛋白定量明显下降(P<0.01),血白蛋白(Alb)水平升高(P<0.01),疗效优于苯那普利组。结论:巴曲酶联合雷公藤多甙、苯那普利治疗Lee氏分级均≥Ⅲ级且伴慢性肾功能不全的IgAN,可以减轻蛋白尿、改善和稳定肾功能,疗效优于单用苯那普利者。
Objective ： To observe the effect of batroxobin combined with benazeprll and tripterigium wilfordii glycosides on IgA nephropathy（IgAN）. Methods： Eighty-four cases with IgAN, whose renal function was chronic insufficiency and renal pathologic change was no less than grade Ⅲ according to Lee＇ s method, were randomly divided into two groups：batroxobin, benazepril and tripterigium wilfordii glycosides group （BBT triplet） and benazepril group, the results were observed respectively. Results： ① After six months, Bun and Scr in BBT triplet group were significantly decreased （the former P 〈 0.01, the latter P 〈 0.05 ）, the effective treatment precedes that of benazepril group. ②After six months, urinary protein quantitative obviously descend （ P 〈 0.01） ,and albumin elevate （ P 〈 0.01）, the effective treatment surpass that of benazepril group. Conclusion ： The effect of batroxobin combined with benazepril and tripterigium wilfordii glycosides on IgAN （≥ Ⅲ by Lee＇s）with renal insufficiency precedes that of single benazepril group in relief of proteinuria, improvement and stabilization of renal function.
出处
《河南医学研究》
CAS
2006年第3期226-228,共3页
Henan Medical Research
关键词
IGA肾病
巴曲酶
血管紧张素转换酶抑制剂
雷公藤多甙
IgA nephropathy
batroxobin
tripterigium wilfordii glycosides
angiotensin converting enzyme inhibitor
