摘要
目的探讨生长激素联合低热量肠外营养(PN)疗法对多器官衰竭(MOF)病人的影响。方法选择40例多器官衰竭病人,随机分为两组,治疗组20例,采用(PN)+重组人生长激素(rhGH)治疗,剂量为8u/d,皮下注射;对照组20例,只采用PN治疗,连续7天。监测所有病人的相关指标。结果所有病人在治疗前血清白蛋白、血清转铁蛋白、血清前白蛋白、免疫指标均明显降低,处于负氮平衡。应用rhGH后治疗组病人第8日血清白蛋白、血清转铁蛋白、血清前白蛋白均明显高于治疗前及对照组(P均<0.05),负氮平衡得到纠正(P<0.05),而对照组病人治疗前后差异不明显(P>0.05),仍处于负氮平衡(P>0.05);治疗组IgA、IgM、IgG均明显高于治疗前及对照组(P均<0.01),而对照组仅IgG高于治疗前(P<0.01);治疗组患者有6例(30%)出现血糖升高,而对照组仅有4例(20%),至15天时对照组病死率为45%,而治疗组仅为15%(P<0.01)。结论合理使用rhGH+PN疗法,能有效纠正MOF病人的营养代谢障碍,增强免疫功能,降低并发症的发生率和病死率。*
Objective To investigate the effect of recombinant human growth hormone（rhGH） and hypocaloric parenteral nutrition （PN）on multiple organ failure（MOF）. Methods 40 postoperative MOF patients were randomized in 2 groups,namely PN ＋ rhGH 8u/d was subcutaneously injected in treatment group 20 control patients treated with PN aLone Nutritional markers and immune markers were detected in several time points. Results Serum albumin proalbumin, transferring were decreased in all patients until 8th day of rhGH treatment. The albumin and proalbumin were improved significantly in rhGH. In control and before treatmentgroups（P 〈 0.05 ） ,only IgG were improved com- pared with before treatment in control group（P 〈0.01 ）. the incidence of complications was remarkedly lower in rhGH group than in control （ 15% vs45% , P 〈 0.01 ）. Conclusion The results suggests that PN ＋ rhGH has much more effects on protein metabolism and immune function on multiple organ failure patients.
出处
《青海医学院学报》
CAS
2006年第3期215-218,共4页
Journal of Qinghai Medical College
关键词
生长激素
低热量肠外营养
多器官衰竭
Growth hormone Hypocaloric parenteral nutrition Muhriple organ failure
