摘要
目的:分析乙型肝炎病毒(HBV)前S1抗原与其他HBV标志物的关系,并探讨其相应的临床意义。方法:用酶联免疫吸附试验方法(ELISA)检测95例HBV病毒感染者血清标志物和前S1抗原,并对结果进行分析。结果:前S1抗原在HBeAg阳性组合中的检出率明显高于HBeAg阴性组合者(P<0.05);HBV感染者抗HBc-IgM与前S1抗原检出率差异有显著性(P<0.05),HbcAb-IgM与前S1抗原的关系不密切(r=-0.1045)。结论:前S1抗原是反映HBV感染、复制的指标,与HBV标志物联合检测可为乙型肝炎的诊断、治疗提供更可靠的依据。
Objective：To investigate the correlation studies on hepatitis B virus pre-S1 protein and standard HBV markers in patients with hepatitis B and explore its clinic values.Methods：Samples collected from 95 hepatitis B patients were analyzed in the study. The HBV Pre-S1 antigen and standard HBV markers （HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc） were analyzed by ELISA. Results：The positive rate of Pre-S1 antigen in the HBeAg（＋） group was higher than that in the HBeAg（-） group （P〈0.05）. It was found that positive rates of Pre S1 and anti-HBc-IgM were significant difference （P〈0.05）, It was found that Pre S1 were correlated with Anti-HBc-IgM with the coefficient being -0.1045.Conclusion：Pre-Slantigen is a satisfactory mark to reflex Hepatitis B Virus is existing or replication, and it can be regarded as a supplementary for hepatitis B markers to early diagnosis of hepatitis B virus infection.
出处
《现代医药卫生》
2006年第21期3243-3244,共2页
Journal of Modern Medicine & Health
