摘要
目的:研究热痹清片在小鼠体内的药物动力学过程。方法:采用药物累积法,以小鼠急性死亡率为指标,测定小鼠灌胃给药后不同时间的药物体存量,估算表观药物动力学参数。结果:药物毒性效应呈一级动力学过程,符合二房室模型。其动力学参数为:分布速率常数α和消除速率常数β分别为2.2272h-1及0.2031h-1;其分布半衰期t1/2α和消除半衰期t1/2β分别为0.3112h和3.4121h。结论:热痹清片小鼠灌胃给药易于吸收,毒性较大,分布快,但消除较慢。其表观药物动力学参数可为临床合理用药作参考。
Objective： Research on pharmacodynamics of the Chinese medicine Rebiqing tablet in mouse intimate. Methods： Adopting drug accumulation , and using the mouse acute mortality rate as indicators to measure the different times after intragastrlc administration of the mouse and estimate apparent pharmacokinetics parameters. Results ： The effect of drug - toxicity shows the first order processes, and it consistents with the two compartment model. Its kinesics parameters as follow：α were 2. 2272 h^-1 and 13 were 0.2031 h^-1 ; t1/2α is 0. 3112h and relimination half life t1/2β is 3.4121h. Conclusion： The Rebiqing tablet is easy to absorb . It distributes fast and eliminates slow. Its causing death dosage and pharmacokinetic parameters can provide reference for clinical rational administration.
出处
《辽宁中医杂志》
CAS
北大核心
2006年第9期1171-1172,共2页
Liaoning Journal of Traditional Chinese Medicine
关键词
热痹清片
制马钱子
药物累积法
药物动力学
Rebiqing tablet
Strychnos alkaloids
drug accumulation
pharmacokinetics
