摘要
目的 探讨增强指数（AI）是否为冠心病独立危险因素及其与冠心病严重程度的相关性。方法 将河北医科大学第二医院2003年12月至2004年12月住院的245例冠脉造影患者，分为1支病变组，2支病变组，3支病变组，非冠脉狭窄组。分别记录每个研究对象的临床特征、生化指标、中心动脉压力波形、Jensini法8支主要血管段狭窄计分的总和。结果 冠脉狭窄支数随着AI的增大而增加。AI与冠脉狭窄评分呈显著正相关。以AI≥45％为冠心病阳性界定值，其准确度为91．5％，特异度为92．6％。AI是冠心病独立危险因素，其比值为1．893，95％的可信区间是1．421—2．521。结论 AI是冠心病的独立危险因素，同时它又是冠脉造影确诊的冠心病严重程度的指标之一。
Objective To explore whether augmentation index is an independent risk factor for coronary heart disease or not, and the relationship between augmentation index and coronary artery disease severity. Methods In the study, 245 subjects who were hospitalized between Dec. 2003 and Dec. 2004, were classified into 4 groups and their clinical and biological characteristics and the summary of the scores in each of the eight segment and aortic pressure waveform in ascending aorta were recorded respectively. Results The larger the .augmentation index was, the more the number of coronary stenosis vessels was. Linear regression analysis indicated that augmentation index was significantly correlated with grade of coronary stenosis. When augmentation index was more than 45%, the sensibility and speciificity was 91.5% and 92. 6%respectively. In the logistic regression model, augmentation index was the independent risk factor for coronary heart disease, and the odds ratio of coronary heart disease was 1. 893. The 95% CI was 1. 421 ～ 2. 521. Conclusion Augmentation index is an independent risk factor for coronary heart disease and a predictor of angiographie coronary artery disease severity.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2006年第10期1508-1509,共2页
Chinese Journal of Practical Internal Medicine
基金
河北省卫生厅基金资助项目(05218)
关键词
动脉硬化
增强指数
冠心病
冠脉造影
Artery stiffness
Augmentation index
Coronary heart disease
Coronary angiography
